Raqual Bower
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Explore the profile of Raqual Bower including associated specialties, affiliations and a list of published articles.
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19
Citations
723
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Recent Articles
1.
Fu G, Augspurger K, Sakizadeh J, Reck J, Bower R, Tritschler D, et al.
Mol Biol Cell
. 2024 Apr;
35(5):ar72.
PMID: 38568782
Cilia generate three-dimensional waveforms required for cell motility and transport of fluid, mucus, and particles over the cell surface. This movement is driven by multiple dynein motors attached to nine...
2.
Hwang J, Yanagisawa H, Davis K, Hunter E, Fox L, Jimenez A, et al.
Cytoskeleton (Hoboken)
. 2024 Jan;
81(11):539-555.
PMID: 38224153
To identify proteins specific to the proximal ciliary axoneme, we used iTRAQ to compare short (~2 μm) and full-length (~11 μm) axonemes of Chlamydomonas. Known components of the proximal axoneme...
3.
Fu G, Augspurger K, Sakizadeh J, Reck J, Bower R, Tritschler D, et al.
bioRxiv
. 2023 Aug;
PMID: 37577467
Ciliary motility requires the spatiotemporal coordination of multiple dynein motors by regulatory complexes located within the 96 nm axoneme repeat. Many organisms can alter ciliary waveforms in response to internal...
4.
Saravanan S, Trischler D, Bower R, Porter M, Lechtreck K
Mol Biol Cell
. 2023 Jan;
34(2):br2.
PMID: 36598807
Many axonemal proteins enter cilia and flagella on intraflagellar transport (IFT) trains, which move bidirectionally along the axonemal microtubules. Certain axonemal substructures including the radial spokes and outer dynein arms...
5.
Scaffold subunits support associated subunit assembly in the ciliary nexin-dynein regulatory complex
Gui L, Song K, Tritschler D, Bower R, Yan S, Dai A, et al.
Proc Natl Acad Sci U S A
. 2019 Oct;
116(46):23152-23162.
PMID: 31659045
The nexin-dynein regulatory complex (N-DRC) in motile cilia and flagella functions as a linker between neighboring doublet microtubules, acts to stabilize the axonemal core structure, and serves as a central...
6.
Lin J, Le T, Augspurger K, Tritschler D, Bower R, Fu G, et al.
Mol Biol Cell
. 2019 Sep;
30(21):2659-2680.
PMID: 31483737
Ciliary motility depends on both the precise spatial organization of multiple dynein motors within the 96 nm axonemal repeat and the highly coordinated interactions between different dyneins and regulatory complexes...
7.
Bower R, Tritschler D, Mills K, Heuser T, Nicastro D, Porter M
Mol Biol Cell
. 2017 Nov;
29(2):137-153.
PMID: 29167384
The nexin-dynein regulatory complex (N-DRC) plays a central role in the regulation of ciliary and flagellar motility. In most species, the N-DRC contains at least 11 subunits, but the specific...
8.
Chien A, Shih S, Bower R, Tritschler D, Porter M, Yildiz A
Elife
. 2017 Sep;
6.
PMID: 28930071
Intraflagellar transport (IFT) is essential for the elongation and maintenance of eukaryotic cilia and flagella. Due to the traffic jam of multiple trains at the ciliary tip, how IFT trains...
9.
Lewis W, Malarkey E, Tritschler D, Bower R, Pasek R, Porath J, et al.
PLoS Genet
. 2016 Jul;
12(7):e1006220.
PMID: 27472056
Ciliopathies are genetic disorders arising from dysfunction of microtubule-based cellular appendages called cilia. Different cilia types possess distinct stereotypic microtubule doublet arrangements with non-motile or 'primary' cilia having a 9+0...
10.
Reck J, Schauer A, Mills K, Bower R, Tritschler D, Perrone C, et al.
Mol Biol Cell
. 2016 Jun;
27(15):2404-22.
PMID: 27251063
The assembly of cilia and flagella depends on the activity of two microtubule motor complexes, kinesin-2 and dynein-2/1b, but the specific functions of the different subunits are poorly defined. Here...