Raphael Thuillet
Overview
Explore the profile of Raphael Thuillet including associated specialties, affiliations and a list of published articles.
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Articles
37
Citations
861
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Recent Articles
1.
Robert F, Benchenouf F, Ha M, Cuomo A, Ottaviani M, Surbier M, et al.
JHEP Rep
. 2025 Feb;
7(3):101297.
PMID: 39980753
Background & Aims: Hepatopulmonary syndrome (HPS) results from portal hypertension, with or without cirrhosis, and is marked by pulmonary vascular dilations leading to severe hypoxemia. Although placental growth factor (PlGF)...
2.
Robert F, Certain M, Baron A, Thuillet R, Duhaut L, Ottaviani M, et al.
Am J Respir Crit Care Med
. 2024 Apr;
210(5):648-661.
PMID: 38626313
Hepatopulmonary syndrome (HPS) is a severe complication of liver diseases characterized by abnormal dilation of pulmonary vessels, resulting in impaired oxygenation. Recent research highlights the pivotal role of liver-produced BMP-9...
3.
Jutant E, Chelgham M, Ottaviani M, Thuillet R, Le Vely B, Humbert M, et al.
J Heart Lung Transplant
. 2023 Sep;
43(1):120-133.
PMID: 37704159
Background: Leptin receptor (ObR-b) is overexpressed in pulmonary artery smooth muscle cells (PA-SMCs) from patients with pulmonary arterial hypertension (PAH) and is implicated in both mechanisms that contribute to pulmonary...
4.
Cauvet A, Decellas A, Guignabert C, Rongvaux-Gaida D, Thuillet R, Ottaviani M, et al.
Arthritis Res Ther
. 2023 Sep;
25(1):167.
PMID: 37700377
Background: Uncontrolled T-cell activation plays a key role in systemic sclerosis (SSc). Arsenic trioxide (ATO) has immunological effects and has demonstrated potential in preclinical SSc models. In this study, we...
5.
Avouac J, Cauvet A, Orvain C, Boulch M, Tilotta F, Tu L, et al.
Arthritis Rheumatol
. 2023 Aug;
76(2):268-278.
PMID: 37610259
Objective: Our goal was to study the tolerance and efficacy of two B cell depletion strategies, including one with CD19-targeted chimeric antigen receptor (CAR) T cells, in a preclinical model...
6.
Guignabert C, Savale L, Boucly A, Thuillet R, Tu L, Ottaviani M, et al.
Circulation
. 2023 Apr;
147(24):1809-1822.
PMID: 37096577
Background: Activins are novel therapeutic targets in pulmonary arterial hypertension (PAH). We therefore studied whether key members of the activin pathway could be used as PAH biomarkers. Methods: Serum levels...
7.
Abdelazeem H, Tu L, Thuillet R, Ottaviani M, Boulfrad A, Beck T, et al.
Eur J Pharmacol
. 2023 Mar;
946:175579.
PMID: 36914083
Pulmonary hypertension (PH) is associated with pulmonary vasoconstriction and endothelial dysfunction leading to impaired nitric oxide (NO) and prostacyclin (PGI) pathways. Metformin, the first line treatment for type 2 diabetes...
8.
Inhibition of Soluble Epoxide Hydrolase Does Not Promote or Aggravate Pulmonary Hypertension in Rats
Leuillier M, Platel V, Tu L, Feugray G, Thuillet R, Groussard D, et al.
Cells
. 2023 Feb;
12(4).
PMID: 36831332
Inhibitors of soluble epoxide hydrolase (sEH), which catalyzes the hydrolysis of various natural epoxides to their corresponding diols, present an opportunity for developing oral drugs for a range of human...
9.
Tian S, Cai Z, Sen P, van Uden D, Van de Kamp E, Thuillet R, et al.
Am J Physiol Heart Circ Physiol
. 2022 Sep;
323(5):H958-H974.
PMID: 36149769
Mechanical forces are translated into biochemical stimuli by mechanotransduction channels, such as the mechanically activated cation channel Piezo2. Lung Piezo2 expression has recently been shown to be restricted to endothelial...
10.
Tu L, Thuillet R, Perrot J, Ottaviani M, Ponsardin E, Kolkhof P, et al.
Hypertension
. 2022 Aug;
79(10):2262-2273.
PMID: 35979822
Background: We studied the ability of the nonsteroidal MR (mineralocorticoid receptor) antagonist finerenone to attenuate vascular remodeling and pulmonary hypertension using two complementary preclinical models (the monocrotaline and sugen/hypoxia rat...