Raphael J Witorsch
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Explore the profile of Raphael J Witorsch including associated specialties, affiliations and a list of published articles.
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10
Citations
211
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Recent Articles
1.
Rosol T, Witorsch R
Regul Toxicol Pharmacol
. 2021 May;
124:104961.
PMID: 34015422
Ethyl acrylate (EA) was classified by IARC as a Group-2B Carcinogen based, in part, on data suggesting increased incidence of thyroid neoplasia in rats and mice exposed chronically to EA...
2.
Borgert C, Becker R, Carlton B, Hanson M, Kwiatkowski P, Marty M, et al.
Toxicol Sci
. 2016 May;
151(2):206-13.
PMID: 27208076
There is debate over whether the requirements of GLP are appropriate standards for evaluating the quality of toxicological data used to formulate regulations. A group promoting the importance of non-monotonic...
3.
Witorsch R
Crit Rev Toxicol
. 2016 Feb;
46(5):420-36.
PMID: 26912073
This article reviews the influence of the hypothalamo-pituitary-adrenocortical (HPA) axis on mammalian male and female reproduction and development of offspring and its potential impact on the identification of endocrine disruptive...
4.
Witorsch R
Crit Rev Toxicol
. 2014 Jun;
44(6):535-55.
PMID: 24897554
This review examines the mammalian and human literature pertaining to the potential endocrine disruptive effects of triclosan (TCS). Dietary exposure to TCS consistently produces a dose-dependent decrease in serum thyroxine...
5.
Witorsch R, Thomas J
Crit Rev Toxicol
. 2010 Oct;
40 Suppl 3:1-30.
PMID: 20932229
This article reviews laboratory and epidemiological research into the endocrine disruptive effects of components of personal care products, namely, phthalate esters, parabens, ultraviolet (UV) filters, polycyclic musks, and antimicrobials. High...
6.
Goodman J, Witorsch R, McConnell E, Sipes I, Slayton T, Yu C, et al.
Crit Rev Toxicol
. 2008 Oct;
39(1):1-75.
PMID: 18923974
Recent public concern has focused on potential reproductive and developmental effects from exposure to low levels of bisphenol A (BPA, CAS number 80-05-7). Two previous published reviews (Gray et al.,...
7.
Goodman J, McConnell E, Sipes I, Witorsch R, Slayton T, Yu C, et al.
Crit Rev Toxicol
. 2006 Sep;
36(5):387-457.
PMID: 16954066
There is controversy over whether low doses of bisphenol A (BPA, CAS no. 80-05-7) cause reproductive and developmental effects in humans. We update the 2004 weight-of-evidence assessment of an expert...
8.
Cooke P, Holsberger D, Witorsch R, Sylvester P, Meredith J, Treinen K, et al.
Toxicol Appl Pharmacol
. 2004 Feb;
194(3):309-35.
PMID: 14761686
A symposium at the 2003 Annual Meeting of the Society of Toxicology brought together an expert group of endocrinologists to review how non-reproductive hormones can affect the endocrine system. This...
9.
Borgert C, LaKind J, Witorsch R
Environ Health Perspect
. 2003 Jun;
111(8):1020-36.
PMID: 12826475
The two primary sources of nutrition for infants are human milk and infant formula. Both contain an array of endogenous and exogenous chemicals that may act through many separate hormonal...
10.
Witorsch R
Regul Toxicol Pharmacol
. 2002 Oct;
36(1):118-30.
PMID: 12383724
A large number of diverse nonsteroidal chemicals, referred to as xenoestrogens, bind to the estrogen receptor (ER) and evoke biological responses. The activity of most xenoestrogens is weak (from about...