Rana Samadfam
Overview
Explore the profile of Rana Samadfam including associated specialties, affiliations and a list of published articles.
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Snapshot
Articles
24
Citations
492
Followers
0
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Recent Articles
1.
Sinha A, Li Y, Khan Mirzaei M, Shamash M, Samadfam R, King I, et al.
Microbiome
. 2022 Jul;
10(1):105.
PMID: 35799219
Background: Inflammatory bowel diseases (IBDs) including Crohn's disease (CD) and ulcerative colitis (UC) are characterized by chronic and debilitating gut inflammation. Altered bacterial communities of the intestine are strongly associated...
2.
Graveline R, Haida M, Dumont C, Poulin D, Poitout-Belissent F, Samadfam R, et al.
MAbs
. 2021 Dec;
14(1):1979447.
PMID: 34923919
Targeting immune checkpoint receptors expressed in the T cell synapse induces active and long-lasting antitumor immunity in preclinical tumor models and oncology patients. However, traditional nonhuman primate (NHP) studies in...
3.
Richard C, Huo R, Samadfam R, Bolivar I, Miao D, Brown E, et al.
J Bone Miner Res
. 2018 Nov;
33(11):2082-2083.
PMID: 30395369
No abstract available.
4.
Chouinard L, Felx M, Mellal N, Varela A, Mann P, Jolette J, et al.
Regul Toxicol Pharmacol
. 2016 Aug;
81:212-222.
PMID: 27569204
Romosozumab is a humanized immunoglobulin G monoclonal antibody that binds and blocks the action of sclerostin, a protein secreted by the osteocyte and an extracellular inhibitor of canonical Wnt signaling....
5.
Pennypacker B, Gilberto D, Gatto N, Samadfam R, Smith S, Kimmel D, et al.
J Orthop Res
. 2015 Jul;
34(1):72-80.
PMID: 26178170
The effects of the cathepsin K inhibitor odanacatib (ODN) on fracture healing were monitored for ~6 and 15 weeks post-fracture in two separate studies using the unilateral transverse mid-ulnar osteotomy...
6.
Smith S, Samadfam R, Chouinard L, Awori M, Benardeau A, Bauss F, et al.
J Bone Miner Metab
. 2014 Dec;
33(6):625-41.
PMID: 25534548
Pioglitazone, the peroxisome proliferator-activated receptor-gamma (PPAR-γ) agonist is an effective therapy for type 2 diabetes, but has been associated with increased risk for bone fracture. Preclinical studies suggest that PPAR-α...
7.
Takeda S, Smith S, Tamura T, Saito H, Takahashi F, Samadfam R, et al.
Calcif Tissue Int
. 2014 Dec;
96(1):45-55.
PMID: 25467010
The purpose of this study is to estimate the efficacy of eldecalcitol (1α, 25-Dihydroxy-2β- (3-hydroxypropyloxy) vitamin D3; ELD) on bone metabolism after long-term administration. Six-month-old Wistar-Imamichi rats were ovariectomized (OVX)...
8.
Kostenuik P, Smith S, Samadfam R, Jolette J, Zhou L, Ominsky M
J Bone Miner Res
. 2014 Nov;
30(4):657-69.
PMID: 25369992
Postmenopausal osteoporosis is a chronic disease wherein increased bone remodeling reduces bone mass and bone strength. Antiresorptive agents including bisphosphonates are commonly used to mitigate bone loss and fracture risk....
9.
Gentile M, Soung D, Horrell C, Samadfam R, Drissi H, Duong L
Bone
. 2014 Jun;
66:72-81.
PMID: 24928497
Cathepsin K (CatK) is a cysteine protease, expressed predominantly in osteoclasts (OC) which degrades demineralized bone matrix. Novel selective inhibitors of CatK are currently being developed for the treatment of...
10.
Pennypacker B, Chen C, Zheng H, Shih M, Belfast M, Samadfam R, et al.
J Bone Miner Res
. 2014 Mar;
29(8):1847-58.
PMID: 24591096
Treatment with the cathepsin K (CatK) inhibitor odanacatib (ODN) protects against bone loss and maintains normal biomechanical properties in the spine and hip of ovariectomized (OVX) preclinical models. Here, we...