Ramkumar Thiyagarajan
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Explore the profile of Ramkumar Thiyagarajan including associated specialties, affiliations and a list of published articles.
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22
Citations
169
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Recent Articles
1.
Thiyagarajan R, Zhang L, Glover O, Kwack K, Ahmed S, Murray E, et al.
Aging Cell
. 2024 Aug;
23(11):e14298.
PMID: 39180173
An aged immune system undergoes substantial changes where myelopoiesis dominates within the bone marrow. Monocytic-MDSCs (M-MDSCs) have been found to play an important role in osteoclastogenesis and bone resorption. In...
2.
Zanotto T, Pradeep Kumar D, Tabatabaei A, Lynch S, He J, Herda T, et al.
Pilot Feasibility Stud
. 2024 Apr;
10(1):65.
PMID: 38650042
Background: Frailty, a syndrome characterized by decreased reserve and resistance to stressors across multiple physiologic systems, is highly prevalent in people living with multiple sclerosis (pwMS), independent of age or...
3.
Choudhury D, Rong N, Senthil Kumar H, Swedick S, Samuel R, Mehrotra P, et al.
Cell Rep
. 2024 Feb;
43(2):113738.
PMID: 38354087
Mitochondrial dysfunction is a hallmark of cellular senescence, with the loss of mitochondrial function identified as a potential causal factor contributing to senescence-associated decline in cellular functions. Our recent findings...
4.
Thiyagarajan R, Taub M
Int J Mol Sci
. 2023 Dec;
24(23).
PMID: 38069326
Cystinosis is an autosomal recessive disease resulting from mutations in , which encodes for cystinosin, a proton-coupled cystine transporter that exports cystine from lysosomes. The major clinical form, infantile cystinosis,...
5.
Zhang L, Kwack K, Thiyagarajan R, Mullaney K, Lamb N, Bard J, et al.
FASEB J
. 2023 Dec;
38(1):e23338.
PMID: 38038723
Tristetraprolin (TTP; also known as NUP475, GOS24, or TIS11), encoded by Zfp36, is an RNA-binding protein that regulates target gene expression by promoting mRNA decay and preventing translation. Although previous...
6.
Thiyagarajan R, Rodriguez Gonzalez M, Zaw C, Seldeen K, Hernandez M, Pang M, et al.
J Bone Res
. 2023 Sep;
11(4).
PMID: 37711761
Background: Osteoclastic bone resorption markedly increases with aging, leading to osteoporosis characterized by weak and fragile bones. Mice exhibit greater bone resorption and poor bone mass when Sirt1 is removed...
7.
Rajabian N, Ikhapoh I, Shahini S, Choudhury D, Thiyagarajan R, Shahini A, et al.
Nat Commun
. 2023 Feb;
14(1):886.
PMID: 36797255
We investigate the age-related metabolic changes that occur in aged and rejuvenated myoblasts using in vitro and in vivo models of aging. Metabolic and signaling experiments reveal that human senescent...
8.
Choudhury D, Rong N, Ikhapoh I, Rajabian N, Tseropoulos G, Wu Y, et al.
Cell Rep
. 2022 Nov;
41(9):111744.
PMID: 36450260
Mitochondrial dysfunction, a hallmark of aging, has been associated with the onset of aging phenotypes and age-related diseases. Here, we report that impaired mitochondrial function is associated with increased glutamine...
9.
Kwack K, Zhang L, Kramer E, Thiyagarajan R, Lamb N, Arao Y, et al.
Front Immunol
. 2022 Oct;
13:1002163.
PMID: 36263047
Aging results in enhanced myelopoiesis, which is associated with an increased prevalence of myeloid leukemias and the production of myeloid-derived suppressor cells (MDSCs). Tristetraprolin (TTP) is an RNA binding protein...
10.
Shahini A, Rajabian N, Choudhury D, Shahini S, Vydiam K, Nguyen T, et al.
Sci Adv
. 2021 Sep;
7(36):eabe5671.
PMID: 34516892
Senescence of myogenic progenitors impedes skeletal muscle regeneration. Here, we show that overexpression of the transcription factor NANOG in senescent myoblasts can overcome the effects of cellular senescence and confer...