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Ram Prajit

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Articles 7
Citations 52
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Recent Articles
1.
Prajit R, Sritawan N, Aranarochana A, Sirichoat A, Pannangrong W, Wigmore P, et al.
Biogerontology . 2025 Mar; 26(2):70. PMID: 40085327
Aged-related cognitive impairments are associated with molecular neurodegenerations and impeded neurogenesis in the dentate gyrus (DG) of the damaged hippocampus. Neurogenesis requires activated cyclic AMP-responsive element-binding protein (CREB) pathway to...
2.
Kaewngam S, Prajit R, Anosri T, Suwannakot K, Saenno R, Sritawan N, et al.
Sci Rep . 2024 Nov; 14(1):28864. PMID: 39572680
Treatment with valproic acid (VPA) can induce oxidative stress, leading to neuronal degeneration. Hesperidin (HSD) has an antioxidant function that can mitigate oxidative stress, thereby promoting hippocampal neurogenesis. Because brain...
3.
Saenno R, Suwannakot K, Prajit R, Sirichoat A, Aranarochana A, Sritawan N, et al.
Mol Neurobiol . 2024 Nov; 62(4):5143-5155. PMID: 39516391
Aging is a main factor related to cognitive deficits. D-Galactose (D-gal), a monosaccharide, increases oxidative stress leading to cellular senescence, memory deficits, and neuronal apoptosis. Caffeic acid (CA) is an...
4.
Prajit R, Saenno R, Suwannakot K, Kaewngam S, Anosri T, Sritawan N, et al.
Biogerontology . 2024 Sep; 25(6):1275-1284. PMID: 39300009
Oxidative stress-induced neuronal apoptosis is primarily involved in brain aging and impaired hippocampal neurogenesis. Long-term D-galactose administration increases oxidative stress related to brain aging. Chrysin, a subtype of flavonoids, exhibits...
5.
Naewla S, Prajit R, Sritawan N, Suwannakot K, Sirichoat A, Aranarochana A, et al.
Biomed Pharmacother . 2023 Aug; 166:115329. PMID: 37597319
Neurogenesis is a process of generating neural stem cells (NSCs) as functional neurons can be decreased after chemotherapy treatments. Methotrexate (MTX) is a folate antagonist that is used for cancer...
6.
Suwannakot K, Sritawan N, Prajit R, Aranarochana A, Sirichoat A, Pannangrong W, et al.
Antioxidants (Basel) . 2021 Apr; 10(4). PMID: 33923672
Melatonin is an endogenous hormone that exhibits antioxidant functions and neuroprotective effects. The hippocampus and the prefrontal cortex (PFC) play an important role linked to working memory. 5-fluorouracil (5-FU) can...
7.
Sritawan N, Prajit R, Chaisawang P, Sirichoat A, Pannangrong W, Wigmore P, et al.
Biomed Pharmacother . 2020 Aug; 131:110651. PMID: 32841896
Methotrexate (MTX) is a chemotherapeutic drug commonly used to treat cancers that has an adverse effect on patients' cognition. Metformin is a primary treatment for type 2 diabetes mellitus that...
8.
Prajit R, Sritawan N, Suwannakot K, Naewla S, Aranarochana A, Sirichoat A, et al.
Nutrients . 2020 Apr; 12(4). PMID: 32316121
The interruption of hippocampal neurogenesis due to aging impairs memory. The accumulation of D-galactose (D-gal), a monosaccharide, induces brain aging by causing oxidative stress and inflammation, resulting in neuronal cell...