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Ralph Hb Benedict

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Articles 58
Citations 1245
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Recent Articles
1.
Benedict R, Kappos L, Miller A, Hartung H, Overell J, Pei J, et al.
Mult Scler Relat Disord . 2025 Feb; 95:106310. PMID: 39965438
Background: Cognitive impairment is a well-recognized symptom of multiple sclerosis (MS) that can manifest early in the disease course. Deficits in cognitive function can have a major impact on daily...
2.
Ziccardi S, Guandalini M, Fuchs T, Calabrese M, Benedict R
Mult Scler . 2024 Aug; 30(11-12):1402-1404. PMID: 39193704
Progression independent of relapse activity (PIRA) has been recently proposed in multiple sclerosis (MS) as a model identifying a continuous silent progression of disability without the manifestation of new clinical...
3.
Fuchs T, Schoonheim M, Zivadinov R, Dwyer M, Colato E, Weinstock Z, et al.
Mult Scler . 2024 Aug; 30(11-12):1468-1478. PMID: 39193699
Background: Substantial physical-disability worsening in relapsing-remitting multiple sclerosis (RRMS) occurs outside of clinically recorded relapse. This phenomenon, termed progression independent of relapse activity (PIRA), is yet to be established for...
4.
Zivadinov R, Bergsland N, Jakimovski D, Weinstock-Guttman B, Lorefice L, Schoonheim M, et al.
Neuroimage Clin . 2024 May; 42:103609. PMID: 38718640
Background: Prior research has established a link between thalamic pathology and cognitive impairment (CI) in people with multiple sclerosis (pwMS). However, the translation of these findings to pwMS in everyday...
5.
Jakimovski D, Weinstock-Guttman B, Burnham A, Weinstock Z, Wicks T, Ramanathan M, et al.
Mult Scler Relat Disord . 2024 Apr; 87:105630. PMID: 38678969
Background: Expanded Disability Status Scale (EDSS) is limited when utilized in highly disabled people with multiple sclerosis (pwMS). Objetive: To explore the relationship between disability measures and MRI outcomes in...
6.
Jalaleddini K, Jakimovski D, Keshavan A, McCurdy S, Leyden K, Qureshi F, et al.
Ann Clin Transl Neurol . 2024 Jan; 11(3):729-743. PMID: 38234075
Background: A quantitative measurement of serum proteome biomarkers that would associate with disease progression endpoints can provide risk stratification for persons with multiple sclerosis (PwMS) and supplement the clinical decision-making...
7.
Jakimovski D, Bittner S, Zivadinov R, Morrow S, Benedict R, Zipp F, et al.
Lancet . 2023 Nov; 403(10422):183-202. PMID: 37949093
Multiple sclerosis remains one of the most common causes of neurological disability in the young adult population (aged 18-40 years). Novel pathophysiological findings underline the importance of the interaction between...
8.
Ziccardi S, Fuchs T, Dwyer M, Zivadinov R, Hulst H, Calabrese M, et al.
Mult Scler . 2023 Nov; 30(3):448-452. PMID: 37942544
Background: Cognitive phenotyping may be useful for predicting rehabilitation response in multiple sclerosis. Objective: To evaluate the association between cognitive phenotype(s) and response to restorative cognitive rehabilitation (RRCR). Methods: In...
9.
Weinstock Z, Jaworski 3rd M, Dwyer M, Jakimovski D, Burnham A, Wicks T, et al.
Mult Scler . 2023 Oct; 29(13):1646-1658. PMID: 37842763
Background: The Symbol Digit Modalities Test (SDMT) is a gold-standard measure of cognitive efficiency and processing speed for people with multiple sclerosis (PwMS) but relies on vision and oculomotor function....
10.
Jaworski 3rd M, Gillies J, Youngs M, Wojcik C, Santivasci C, Jakimovski D, et al.
Mult Scler . 2023 Jul; 29(10):1327-1336. PMID: 37503838
Background: Employment deterioration is common in people with multiple sclerosis (PwMS). Clinicians often learn of job loss after its occurrence, leaving no opportunity for preventive measures. Objectives: Identify which neuropsychological...