Ralf Hoffmann
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Explore the profile of Ralf Hoffmann including associated specialties, affiliations and a list of published articles.
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Articles
243
Citations
3754
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Recent Articles
1.
Schwarze M, Brakel A, Hoffmann R, Krizsan A
ChemMedChem
. 2025 Feb;
:e202400973.
PMID: 39996354
New strategies are needed to prevent and control upcoming outbreaks of SARS-CoV-2 infections, independent of vaccination. SARS-CoV-2 binds to the human ACE-2 receptor through the receptor binding domain (RBD) of...
2.
Cardador M, Kruger S, Dunker S, Brakel A, Hoffmann R, Nagel R, et al.
Plant J
. 2025 Feb;
121(3):e17238.
PMID: 39924694
The unicellular soil alga Chlamydomonas reinhardtii forms diploid zygotes during its sexual cycle. The process of a zygote maturing into a highly resistant zygospore remains poorly understood despite its importance...
3.
Lauer S, Gasse J, Krizsan A, Reepmeyer M, Sprink T, Nikolay R, et al.
Nat Commun
. 2025 Jan;
16(1):567.
PMID: 39794318
The proline-rich antimicrobial designer peptide Api137 inhibits protein expression in bacteria by binding simultaneously to the ribosomal polypeptide exit tunnel and the release factor (RF), depleting the cellular RF pool...
4.
Lauer S, Reepmeyer M, Berendes O, Klepacki D, Gasse J, Gabrielli S, et al.
Nat Commun
. 2024 May;
15(1):3945.
PMID: 38730238
Proline-rich antimicrobial peptides (PrAMPs) inhibit bacterial protein biosynthesis by binding to the polypeptide exit tunnel (PET) near the peptidyl transferase center. Api137, an optimized derivative of honeybee PrAMP apidaecin, inhibits...
5.
Rottmayer K, Schwarze M, Jassoy C, Hoffmann R, Loeffler-Wirth H, Lehmann C
Biology (Basel)
. 2024 Apr;
13(4).
PMID: 38666885
Serological assays for SARS-CoV-2 play a pivotal role in the definition of whether patients are infected, the understanding of viral epidemiology, the screening of convalescent sera for therapeutic and prophylactic...
6.
Schwarze M, Volke D, Rojas Echeverri J, Schick R, Lakowa N, Grunewald T, et al.
Biology (Basel)
. 2024 Apr;
13(4).
PMID: 38666819
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) can infect human cells by first attaching to the ACE-2 receptor via its receptor-binding domain (RBD) in the spike protein. Here, we report...
7.
Jentsch M, Lubke S, Schrodl W, Volke D, Krizsan A, Hoffmann R, et al.
Front Immunol
. 2024 Mar;
15:1347164.
PMID: 38487534
Introduction: Severe equine asthma (SEA) is a common chronic disease of adult horses with characteristic recurrent airway obstruction and similarities to neutrophilic asthma in humans. As an extrinsic stimulus, hay...
8.
De Spiegeleer A, Descamps A, Wynendaele E, Naumovski P, Crombez L, Planas M, et al.
Biochim Biophys Acta Mol Basis Dis
. 2024 Mar;
1870(4):167094.
PMID: 38428683
Muscle wasting diseases, such as cancer cachexia and age-associated sarcopenia, have a profound and detrimental impact on functional independence, quality of life, and survival. Our understanding of the underlying mechanisms...
9.
Selg C, Grell T, Brakel A, Andrews P, Hoffmann R, Hey-Hawkins E
Chempluschem
. 2024 Jan;
89(6):e202300759.
PMID: 38263504
This study proposes an innovative strategy to enhance the pharmacophore model of antimicrobial bismuth thiolato complex drugs by substituting hydrocarbon ligand structures with boron clusters, particularly icosahedral closo-dicarbadodecaborane (CBH, carboranes)....
10.
Brakel A, Grochow T, Fritsche S, Knappe D, Krizsan A, Fietz S, et al.
Front Microbiol
. 2024 Jan;
14:1328890.
PMID: 38260890
Background: Cryptococcosis and cryptococcal meningitis, caused by infections, lead to approximately 180,000 deaths per year, primarily in developing countries. Individuals with compromised immune systems, e.g., due to HIV infection (AIDS)...