Ralf A Linker
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Explore the profile of Ralf A Linker including associated specialties, affiliations and a list of published articles.
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194
Citations
6632
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Recent Articles
1.
Potthoff S, Quack I, Mori Y, Yang G, Arifaj D, Amin E, et al.
Hypertension
. 2025 Jan;
PMID: 39851048
Background: Ciliary neurotrophic factor (CNTF), mainly known for its neuroprotective properties, belongs to the IL-6 (interleukin-6) cytokine family. In contrast to IL-6, the effects of CNTF on the vasculature have...
2.
Wecker S, Freudenstein D, Ganser I, Angstwurm K, Lee D, Linker R
Ther Adv Neurol Disord
. 2024 Nov;
17:17562864241284166.
PMID: 39494114
Background: Multiple sclerosis (MS) is a chronic immune-mediated disease of the central nervous system affecting approximately 2.8 million people worldwide. In addition to genetic and environmental factors, various lifestyle factors...
3.
J Hilz M, Canavese F, de Rojas-Leal C, Lee D, Linker R, Wang R
Clin Auton Res
. 2024 Oct;
PMID: 39382757
Purpose: Vagomimetic fingolimod effects cause heart rate (HR) slowing upon treatment initiation but wear off with sphingosine-1-phosphate receptor downregulation. Yet, prolonged HR slowing may persist after months of fingolimod treatment....
4.
Haase S, Kuhbandner K, Muhleck F, Gisevius B, Freudenstein D, Hirschberg S, et al.
Front Immunol
. 2024 Aug;
15:1367819.
PMID: 39185426
Background: Recent studies provide increasing evidence for a relevant role of lifestyle factors including diet in the pathogenesis of neuroinflammatory diseases such as multiple sclerosis (MS). While the intake of...
5.
Reinhardt C, Angstwurm K, Freudenstein D, Lee D, Wendl C, Linker R
Neurol Res Pract
. 2024 Aug;
6(1):40.
PMID: 39113151
Background: Atrophy of white and grey matter volumes occurs early in the brains of people with multiple sclerosis (pwMS) and has great clinical relevance. In clinical trials, brain atrophy can...
6.
Hoffmann O, Gold R, Meuth S, Linker R, Skripuletz T, Wiendl H, et al.
Ther Adv Neurol Disord
. 2024 Feb;
17:17562864241229325.
PMID: 38332854
Magnetic resonance imaging (MRI) of the brain and spinal cord plays a crucial role in the diagnosis and monitoring of multiple sclerosis (MS). There is conclusive evidence that brain and...
7.
Freudenstein D, Lippert M, Popp J, Aprato J, Wegner M, Sock E, et al.
Sci Rep
. 2023 Dec;
13(1):22272.
PMID: 38097655
Genome-wide association studies identified a single nucleotide polymorphism (SNP) downstream of the transcription factor Sox8, associated with an increased risk of multiple sclerosis (MS). Sox8 is known to influence oligodendrocyte...
8.
Delgado S, Faissner S, Linker R, Rammohan K
J Neurol
. 2023 Oct;
271(4):1515-1535.
PMID: 37906325
The recent success of anti-CD20 monoclonal antibody therapies in the treatment of multiple sclerosis (MS) has highlighted the role of B cells in the pathogenesis of MS. In people with...
9.
Gudi V, Grieb P, Linker R, Skripuletz T
Neural Regen Res
. 2023 Jul;
18(12):2599-2605.
PMID: 37449595
Multiple sclerosis is a multifactorial chronic inflammatory disease of the central nervous system that leads to demyelination and neuronal cell death, resulting in functional disability. Remyelination is the natural repair...
10.
Heinrich F, Cordts I, GuNTHER R, Stolte B, Zeller D, Schroter C, et al.
J Neurol
. 2023 Jun;
270(10):4922-4938.
PMID: 37356024
Background And Objectives: Motor Neuron Diseases (MND) are rare diseases but have a high impact on affected individuals and society. This study aims to perform an economic evaluation of MND...