Rajeswari Jayavaradhan
Overview
Explore the profile of Rajeswari Jayavaradhan including associated specialties, affiliations and a list of published articles.
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Articles
4
Citations
115
Followers
0
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Recent Articles
1.
Jayavaradhan R, Pillis D, Goodman M, Zhang F, Zhang Y, Andreassen P, et al.
Nat Commun
. 2019 Jun;
10(1):2866.
PMID: 31253785
Precise genome editing/correction of DNA double-strand breaks (DSBs) induced by CRISPR-Cas9 by homology-dependent repair (HDR) is limited by the competing error-prone non-homologous end-joining (NHEJ) DNA repair pathway. Here, we define...
2.
Jayavaradhan R, Malik P
Pediatr Clin North Am
. 2018 May;
65(3):465-480.
PMID: 29803277
Sickle cell disease is the most prevalent monogenic disorder worldwide and curative therapies are limited to hematopoietic stem cell transplant to the few with matched donors. Gene therapy has curative...
3.
Jayavaradhan R, Pillis D, Malik P
J Mol Biol
. 2018 May;
431(1):102-110.
PMID: 29751014
The efficient site-specific DNA double-strand breaks (DSB) created by CRISPR/Cas9 has revolutionized genome engineering and has great potential for editing hematopoietic stem/progenitor cells (HSPCs). However, detailed understanding of the variables...
4.
Chandrakasan S, Jayavaradhan R, Ernst J, Shrestha A, Loberg A, Dexheimer P, et al.
Blood
. 2016 Dec;
129(8):1048-1052.
PMID: 27998889
No abstract available.