Rajasekhar N V S Suragani
Overview
Explore the profile of Rajasekhar N V S Suragani including associated specialties, affiliations and a list of published articles.
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13
Citations
448
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Recent Articles
1.
Li J, Fredericks M, Tang M, Cannell M, Joshi S, Kumar R, et al.
FEBS Lett
. 2022 Aug;
596(24):3145-3158.
PMID: 35920165
Cardiomyopathies are ascribed to a variety of etiologies, present with diverse clinical phenotypes, and lack disease-modifying treatments. Mounting evidence implicates dysregulated activin receptor signaling in heart disease and highlights inhibition...
2.
Kumar R, Grinberg A, Li H, Kuo T, Sako D, Krishnan L, et al.
Sci Rep
. 2021 Sep;
11(1):18341.
PMID: 34526551
Ligands of the transforming growth factor-β (TGF-β) superfamily are important targets for therapeutic intervention but present challenges because they signal combinatorially and exhibit overlapping activities in vivo. To obtain agents...
3.
Martinez P, Li R, Ramanathan H, Bhasin M, Pearsall R, Kumar R, et al.
J Cell Mol Med
. 2020 May;
24(11):6162-6177.
PMID: 32351032
In β-thalassaemia, anaemia results from ineffective erythropoiesis characterized by inhibition of late-stage erythroid differentiation. We earlier used luspatercept and RAP-536 protein traps for certain Smad2/3-pathway ligands to implicate Smad2/3-pathway overactivation...
4.
Rasheedi S, Suragani M, Raviprasad P, Ghosh S, Suragani R, Ramaiah K, et al.
Biochimie
. 2015 Jul;
118:36-43.
PMID: 26215376
We earlier reported 'PeIF5B' as a novel factor from Pisum sativum that has sequence similarity to eIF5B (S. Rasheedi, S. Ghosh, M. Suragani et al., P. sativum contains a factor...
5.
Suragani R, Cawley S, Li R, Wallner S, Alexander M, Mulivor A, et al.
Blood
. 2014 May;
123(25):3864-72.
PMID: 24795345
In β-thalassemia, unequal production of α- and β-globin chains in erythroid precursors causes apoptosis and inhibition of late-stage erythroid differentiation, leading to anemia, ineffective erythropoiesis (IE), and dysregulated iron homeostasis....
6.
Suragani R, Cadena S, Cawley S, Sako D, Mitchell D, Li R, et al.
Nat Med
. 2014 Mar;
20(4):408-14.
PMID: 24658078
Erythropoietin (EPO) stimulates proliferation of early-stage erythrocyte precursors and is widely used for the treatment of chronic anemia. However, several types of EPO-resistant anemia are characterized by defects in late-stage...
7.
Suragani R, Zachariah R, Velazquez J, Liu S, Sun C, Townes T, et al.
Blood
. 2012 Apr;
119(22):5276-84.
PMID: 22498744
Heme-regulated eIF2α kinase (Hri) is necessary for balanced synthesis of heme and globin. In addition, Hri deficiency exacerbates the phenotypic severity of β-thalassemia intermedia in mice. Activation of Hri during...
8.
Liu S, Bhattacharya S, Han A, Suragani R, Zhao W, Fry R, et al.
Br J Haematol
. 2008 Jul;
143(1):129-37.
PMID: 18665838
Haem-regulated eIF2alpha kinase (HRI) is essential for the regulation of globin gene translation and the survival of erythroid precursors in iron/haem deficiency. This study found that that in iron deficiency,...
9.
Rajesh K, Iyer A, Suragani R, Ramaiah K
Biochem Biophys Res Commun
. 2008 Jul;
374(2):336-40.
PMID: 18639529
Purified recombinant human subunits of eukaryotic initiation factor 2 (eIF2) expressed in bacteria are found to interact with each other to form alphabeta, alphagamma, and betagamma complexes in a pull-down...
10.
Liu S, Suragani R, Han A, Zhao W, Andrews N, Chen J
Haematologica
. 2008 Mar;
93(5):753-6.
PMID: 18367482
Heme-regulated eIF2alpha kinase (HRI) is essential for regulating globin translation in iron deficiency and in beta-thalassemia. We investigated the role of heme-regulated eIF2alpha kinase in hemoglobin and red blood cell...