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» Authors » Raja Ebsim

Raja Ebsim

Explore the profile of Raja Ebsim including associated specialties, affiliations and a list of published articles. Areas
Snapshot
Articles 11
Citations 57
Followers 0
Related Specialties
Rheumatology
Biomedical Engineering
Orthopedics
Top 10 Co-Authors
Claudia Lindner
Benjamin G Faber
Fiona R Saunders
Monika Frysz
Jonathan H Tobias
Richard M Aspden
Nicholas C Harvey
Jennifer S Gregory
Timothy Cootes
George Davey Smith
Published In
J Bone Miner Res
Bone
EBioMedicine
Hum Mol Genet
Comput Biol Med
Affiliations
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Recent Articles
1.
A novel classifier of radiographic knee osteoarthritis for use on knee DXA images is predictive of joint replacement in UK Biobank
Beynon R, Saunders F, Ebsim R, Faber B, Jung M, Gregory J, et al.
Rheumatol Adv Pract . 2025 Feb; 9(1):rkaf009. PMID: 39991690
Objectives: DXA scans may offer a novel means of evaluating radiographic knee OA (rKOA) in large population studies and through opportunistic screening. We aimed to develop and apply a semi-automated...
2.
The genetic architecture of hip shape and its role in the development of hip osteoarthritis and fracture
Faber B, Frysz M, Zheng J, Lin H, Flynn K, Ebsim R, et al.
Hum Mol Genet . 2024 Nov; 34(3):207-217. PMID: 39574169
Objectives: Hip shape is thought to be an important causal risk factor for hip osteoarthritis and fracture. We aimed to identify genetic determinants of hip shape and use these to...
3.
Dual-energy X-ray absorptiometry derived knee shape may provide a useful imaging biomarker for predicting total knee replacement: Findings from a study of 37,843 people in UK Biobank
Beynon R, Saunders F, Ebsim R, Frysz M, Faber B, Gregory J, et al.
Osteoarthr Cartil Open . 2024 Apr; 6(2):100468. PMID: 38655015
Objective: We aimed to create an imaging biomarker for knee shape using knee dual-energy x-ray absorptiometry (DXA) scans and investigate its potential association with subsequent total knee replacement (TKR), independently...
4.
Femoral neck width genetic risk score is a novel independent risk factor for hip fractures
Tobias J, Nethander M, Faber B, Heppenstall S, Ebsim R, Cootes T, et al.
J Bone Miner Res . 2024 Mar; 39(3):241-251. PMID: 38477772
Femoral neck width (FNW) derived from DXA scans may provide a useful adjunct to hip fracture prediction. Therefore, we investigated whether FNW is related to hip fracture risk independently of...
5.
Comparison between UK Biobank and Shanghai Changfeng suggests distinct hip morphology may contribute to ethnic differences in the prevalence of hip osteoarthritis
Zheng J, Frysz M, Faber B, Lin H, Ebsim R, Ge J, et al.
Osteoarthritis Cartilage . 2023 Nov; PMID: 37935324
Objects: Joint morphology is a risk factor for hip osteoarthritis (HOA) and could explain ethnic differences in HOA prevalence. Therefore, we aimed to compare the prevalence of radiographic HOA (rHOA)...
6.
The identification of distinct protective and susceptibility mechanisms for hip osteoarthritis: findings from a genome-wide association study meta-analysis of minimum joint space width and Mendelian randomisation cluster analyses
Faber B, Frysz M, Boer C, Evans D, Ebsim R, Flynn K, et al.
EBioMedicine . 2023 Aug; 95:104759. PMID: 37619450
Background: Hip minimum joint space width (mJSW) provides a proxy for cartilage thickness. This study aimed to conduct a genome-wide association study (GWAS) of mJSW to (i) identify new genetic...
7.
A Genome-Wide Association Study Meta-Analysis of Alpha Angle Suggests Cam-Type Morphology May Be a Specific Feature of Hip Osteoarthritis in Older Adults
Faber B, Frysz M, Hartley A, Ebsim R, Boer C, Saunders F, et al.
Arthritis Rheumatol . 2023 Jan; 75(6):900-909. PMID: 36662418
Objective: To examine the genetic architecture of cam morphology using alpha angle (AA) as a proxy measure and conduct an AA genome-wide association study (GWAS) followed by Mendelian randomization (MR)...
8.
Deriving alpha angle from anterior-posterior dual-energy x-ray absorptiometry scans: an automated and validated approach
Faber B, Ebsim R, Saunders F, Frysz M, Davey Smith G, Cootes T, et al.
Wellcome Open Res . 2022 Sep; 6:60. PMID: 36072553
Alpha angle (AA) is a widely used imaging measure of hip shape that is commonly used to define cam morphology, a bulging of the lateral aspect of the femoral head....
9.
Machine Learning-Derived Acetabular Dysplasia and Cam Morphology Are Features of Severe Hip Osteoarthritis: Findings From UK Biobank
Frysz M, Faber B, Ebsim R, Saunders F, Lindner C, Gregory J, et al.
J Bone Miner Res . 2022 Jul; 37(9):1720-1732. PMID: 35811326
The contribution of shape changes to hip osteoarthritis (HOA) remains unclear, as is the extent to which these vary according to HOA severity. In the present study, we used statistical...
10.
A novel semi-automated classifier of hip osteoarthritis on DXA images shows expected relationships with clinical outcomes in UK Biobank
Faber B, Ebsim R, Saunders F, Frysz M, Lindner C, Gregory J, et al.
Rheumatology (Oxford) . 2021 Dec; 61(9):3586-3595. PMID: 34919677
Objective: Conventional scoring methods for radiographic hip OA (rHOA) are subjective and show inconsistent relationships with clinical outcomes. To provide a more objective rHOA scoring method, we aimed to develop...