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Rainer W Friedrich

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Articles 66
Citations 2362
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Recent Articles
1.
ONeill P, Baccino-Calace M, Rupprecht P, Lee S, Hao Y, Lin M, et al.
Elife . 2025 Mar; 13. PMID: 40042890
Quantitative information about synaptic transmission is key to our understanding of neural function. Spontaneously occurring synaptic events carry fundamental information about synaptic function and plasticity. However, their stochastic nature and...
2.
Meissner-Bernard C, Jenkins B, Rupprecht P, Bouldoires E, Zenke F, Friedrich R, et al.
Cell Rep . 2025 Feb; 44(3):115330. PMID: 39985769
Models of balanced autoassociative memory networks predict that specific inhibition is critical to store information in connectivity. To explore these predictions, we characterized and manipulated different subtypes of fast-spiking interneurons...
3.
Meissner-Bernard C, Zenke F, Friedrich R
Elife . 2025 Jan; 13. PMID: 39804831
Biological memory networks are thought to store information by experience-dependent changes in the synaptic connectivity between assemblies of neurons. Recent models suggest that these assemblies contain both excitatory and inhibitory...
4.
Hu B, Temiz N, Chou C, Rupprecht P, Meissner-Bernard C, Titze B, et al.
bioRxiv . 2024 Nov; PMID: 39605658
Higher brain functions depend on experience-dependent representations of relevant information that may be organized by attractor dynamics or by geometrical modifications of continuous "neural manifolds". To explore these scenarios we...
5.
Hu B, Friedrich R
Nat Neurosci . 2024 Nov; 27(12):2273-2275. PMID: 39592794
No abstract available.
6.
Anneser L, Satou C, Hotz H, Friedrich R
Curr Biol . 2023 Dec; 34(2):298-312.e4. PMID: 38157860
The function of neuronal networks is determined not only by synaptic connectivity but also by neuromodulatory systems that broadcast information via distributed connections and volume transmission. To understand the molecular...
7.
Satou C, Neve R, Oyibo H, Zmarz P, Huang K, Bouldoires E, et al.
Elife . 2022 Jul; 11. PMID: 35866706
The zebrafish is an important model in systems neuroscience but viral tools to dissect the structure and function of neuronal circuitry are not established. We developed methods for efficient gene...
8.
Vergara H, Pape C, Meechan K, Zinchenko V, Genoud C, Wanner A, et al.
Cell . 2021 Aug; 184(18):4819-4837.e22. PMID: 34380046
Animal bodies are composed of cell types with unique expression programs that implement their distinct locations, shapes, structures, and functions. Based on these properties, cell types assemble into specific tissues...
9.
Rupprecht P, Carta S, Hoffmann A, Echizen M, Blot A, Kwan A, et al.
Nat Neurosci . 2021 Aug; 24(9):1324-1337. PMID: 34341584
Inference of action potentials ('spikes') from neuronal calcium signals is complicated by the scarcity of simultaneous measurements of action potentials and calcium signals ('ground truth'). In this study, we compiled...
10.
Satou C, Friedrich R
Neuron . 2021 May; 109(10):1590-1592. PMID: 34015265
In this issue of Neuron, Gurnani and Silver (2021) report that activity across Golgi cells, a major type of inhibitory interneuron in the cerebellar cortex, is multidimensional and modulated by...