Rainer Spanagel
Overview
Explore the profile of Rainer Spanagel including associated specialties, affiliations and a list of published articles.
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Articles
278
Citations
8439
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Recent Articles
1.
Meinhardt M, Skorodumov I, Jeanblanc J, Benvenuti F, Hilal F, Domi E, et al.
Neuropsychopharmacology
. 2025 Feb;
PMID: 40021941
The drug development process in psychiatry faces significant challenges due to low reproducibility rates in animal testing, which often leads to translation failures. To address this issue, we introduce a...
2.
Zillich E, Artioli A, Rossetti A, Avetyan D, Belschner H, Frank J, et al.
Cell Rep
. 2025 Feb;
44(2):115332.
PMID: 39954253
Epigenome, transcriptome, and proteome analyses of postmortem brains have revealed initial molecular insights into cocaine use disorder (CUD). However, the inter-relationship between these omics and the contribution of individual cell...
3.
Papale A, Morella I, Indrigo M, Bernardi R, Marrone L, Marchisella F, et al.
Elife
. 2025 Feb;
14.
PMID: 39917906
No abstract available.
4.
Liu S, Haucke M, Gross R, Schneider K, Shin J, Arntz F, et al.
Digit Health
. 2025 Jan;
11():20552076241311731.
PMID: 39845518
Background: Advancing evidence-based, tailored interventions for substance use disorders (SUDs) requires understanding temporal directionality while upholding ecological validity. Previous studies identified loneliness and craving as pivotal factors associated with alcohol...
5.
Habelt B, Afanasenkau D, Schwarz C, Domanegg K, Kuchar M, Werner C, et al.
Transl Psychiatry
. 2024 Dec;
14(1):486.
PMID: 39639028
Patients with alcohol use disorder (AUD) who seek treatment show highly variable outcomes. A precision medicine approach with biomarkers responsive to new treatments is warranted to overcome this limitation. Promising...
6.
Spanagel R
Proc Natl Acad Sci U S A
. 2024 Nov;
121(46):e2420068121.
PMID: 39495934
No abstract available.
7.
P Graf A, Hansson A, Spanagel R
Biol Sex Differ
. 2024 Oct;
15(1):78.
PMID: 39407302
Background: Adolescent social isolation (ASI) has profound long-term effects on behavioral and neural development. Despite this, the specific long-term impact of ASI during different adolescent stages and across sexes remain...
8.
White J, Minto M, Willis C, Quach B, Han S, Tao R, et al.
Biol Psychiatry Glob Open Sci
. 2024 Oct;
4(6):100375.
PMID: 39399155
Background: Alcohol use disorder (AUD) has a profound public health impact. However, understanding of the molecular mechanisms that underlie the development and progression of AUD remains limited. Here, we investigated...
9.
Zillich E, Belschner H, Avetyan D, Andrade-Brito D, Martinez-Magana J, Frank J, et al.
Transl Psychiatry
. 2024 Oct;
14(1):428.
PMID: 39384764
Structural and functional changes of the brain are assumed to contribute to excessive cocaine intake, craving, and relapse in cocaine use disorder (CUD). Epigenetic and transcriptional changes were hypothesized as...
10.
Friske M, Torrico E, Haas M, Borruto A, Giannone F, Hade A, et al.
Mol Psychiatry
. 2024 Sep;
30(1):310-326.
PMID: 39242950
Currently available clinical treatments on alcohol use disorder (AUD) exhibit limited efficacy and new druggable targets are required. One promising approach to discover new molecular treatment targets involves the transcriptomic...