Rafael Shimkunas
Overview
Explore the profile of Rafael Shimkunas including associated specialties, affiliations and a list of published articles.
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Articles
16
Citations
257
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0
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Recent Articles
1.
Ma W, Del Rio C, Qi L, Prodanovic M, Mijailovich S, Zambataro C, et al.
Proc Natl Acad Sci U S A
. 2024 Feb;
121(8):e2314914121.
PMID: 38346202
Mavacamten is a FDA-approved small-molecule therapeutic designed to regulate cardiac function at the sarcomere level by selectively but reversibly inhibiting the enzymatic activity of myosin. It shifts myosin toward ordered...
2.
Myosin in autoinhibited state(s), stabilized by mavacamten, can be recruited via inotropic effectors
Ma W, Del Rio C, Qi L, Prodanovic M, Mijailovich S, Zambataro C, et al.
bioRxiv
. 2023 Apr;
PMID: 37090664
Mavacamten is a novel, FDA-approved, small molecule therapeutic designed to regulate cardiac function by selectively but reversibly inhibiting the enzymatic activity of myosin. It shifts myosin towards ordered states close...
3.
Kazemi-Lari M, Shimkunas R, Jian Z, Hegyi B, Izu L, Shaw J, et al.
iScience
. 2022 Aug;
25(9):104810.
PMID: 36034223
[This corrects the article DOI: 10.1016/j.isci.2022.104667.].
4.
Kazemi-Lari M, Shimkunas R, Jian Z, Hegyi B, Izu L, Shaw J, et al.
iScience
. 2022 Jul;
25(7):104667.
PMID: 35860762
The heart pumps blood into circulation against vascular resistance and actively regulates the contractile force to compensate for mechanical load changes. Our experimental data show that cardiomyocytes have a mechano-chemo-transduction...
5.
Kazemi-Lari M, Shaw J, Wineman A, Shimkunas R, Jian Z, Hegyi B, et al.
Int J Eng Sci
. 2021 Oct;
165.
PMID: 34629507
We develop a viscoelastic generalization of the elastic Eshelby inclusion solution, where the inclusion and surrounding matrix are two different viscoelastic solids and the inclusion's eigenstrain is a time-periodic oscillatory...
6.
Hegyi B, Shimkunas R, Jian Z, Izu L, Bers D, Chen-Izu Y
Proc Natl Acad Sci U S A
. 2021 Jul;
118(31).
PMID: 34326268
The heart pumps blood against the mechanical afterload from arterial resistance, and increased afterload may alter cardiac electrophysiology and contribute to life-threatening arrhythmias. However, the cellular and molecular mechanisms underlying...
7.
Izu L, Shimkunas R, Jian Z, Hegyi B, Kazemi-Lari M, Baker A, et al.
Life (Basel)
. 2021 Jun;
11(6).
PMID: 34072584
The heart has two intrinsic mechanisms to enhance contractile strength that compensate for increased mechanical load to help maintain cardiac output. When vascular resistance increases the ventricular chamber initially expands...
8.
Shimkunas R, Hegyi B, Jian Z, Shaw J, Kazemi-Lari M, Mitra D, et al.
Circ Res
. 2021 Feb;
128(6):772-774.
PMID: 33601939
No abstract available.
9.
Hegyi B, Bossuyt J, Griffiths L, Shimkunas R, Coulibaly Z, Jian Z, et al.
Proc Natl Acad Sci U S A
. 2018 Mar;
115(13):E3036-E3044.
PMID: 29531045
Heart failure (HF) following myocardial infarction (MI) is associated with high incidence of cardiac arrhythmias. Development of therapeutic strategy requires detailed understanding of electrophysiological remodeling. However, changes of ionic currents...
10.
Sirish P, Ledford H, Timofeyev V, Thai P, Ren L, Kim H, et al.
Circ Arrhythm Electrophysiol
. 2017 Oct;
10(10).
PMID: 29025768
Background: Intracellular pH (pH) is critical to cardiac excitation and contraction; uncompensated changes in pH impair cardiac function and trigger arrhythmia. Several ion transporters participate in cardiac pH regulation. Our...