Rafael Posada-Duque
Overview
Explore the profile of Rafael Posada-Duque including associated specialties, affiliations and a list of published articles.
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Articles
11
Citations
127
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Recent Articles
1.
Yepes A, Cardona-Galeano W, Herrera-Ramirez A, Rada M, Osorio E, Gonzalez-Molina L, et al.
RSC Med Chem
. 2025 Jan;
PMID: 39867586
In this work, we developed potential multifunctional agents to combat Alzheimer's disease. According to our strategy, fragments of tacrine and donepezil were merged in a unique hybrid structure. After successfully...
2.
Quiroz Y, Aguillon D, Aguirre-Acevedo D, Vasquez D, Zuluaga Y, Baena A, et al.
N Engl J Med
. 2024 Jun;
390(23):2156-2164.
PMID: 38899694
Background: Variants in and (encoding apolipoprotein E and presenilin 1, respectively) alter the risk of Alzheimer's disease. We previously reported a delay of cognitive impairment in a person with autosomal...
3.
Lopez-Murillo C, Hinestroza-Morales S, Henny P, Toledo J, Cardona-Gomez G, Rivera-Gutierrez H, et al.
Front Neuroanat
. 2024 Apr;
18:1339308.
PMID: 38601797
The house wren shows complex song, and the rufous-tailed hummingbird has a simple song. The location of vocal brain areas supports the song's complexity; however, these still need to be...
4.
Henao-Restrepo J, Lopez-Murillo C, Valderrama-Carmona P, Orozco-Santa N, Gomez J, Gutierrez-Vargas J, et al.
Brain Pathol
. 2022 Sep;
33(2):e13119.
PMID: 36130084
In response to brain insults, astrocytes become reactive, promoting protection and tissue repair. However, astroglial reactivity is typical of brain pathologies, including Alzheimer's disease (AD). Considering the heterogeneity of the...
5.
Rada M, Cardona-Galeano W, Quintero-Saumeth J, Sierra K, Osorio E, Gonzalez-Molina L, et al.
ACS Chem Neurosci
. 2022 Sep;
13(18):2681-2698.
PMID: 36074422
As a contribution to the development of new dual/multifunctional drugs, a novel therapeutical scaffold merging key structural features from memantine and M30D was designed, synthesized, and explored for its AChE/BuChE...
6.
Toro-Fernandez L, Zuluaga-Monares J, Saldarriaga-Cartagena A, Cardona-Gomez G, Posada-Duque R
Front Cell Neurosci
. 2021 Nov;
15:643717.
PMID: 34790098
Glutamate excitotoxicity triggers overactivation of CDK5 and increases calcium influx in neural cells, which promotes dendritic retraction, spine loss, increased mitochondrial calcium from the endoplasmic reticulum, and neuronal death. Our...
7.
Chacon-Quintero M, Pineda-Lopez L, Villegas-Lanau C, Posada-Duque R, Cardona-Gomez G
Front Cell Neurosci
. 2021 May;
15:656832.
PMID: 34025357
Dysfunction in the neurovascular unit (NVU) is a key component in the progressive deterioration of Alzheimer's disease (AD) and is critical in vascular dementia. Recent studies have shown that inflammation...
8.
Gonzalez-Molina L, Villar-Vesga J, Henao-Restrepo J, Villegas A, Lopera F, Cardona-Gomez G, et al.
Front Aging Neurosci
. 2021 Mar;
13:593927.
PMID: 33679370
Astrocytes are specialized glial cells that are essential components of the neurovascular unit (NVU) and are involved in neurodevelopment, brain maintenance and repair, and neurodegeneration. Astrocytes mediate these processes by...
9.
Villar-Vesga J, Henao-Restrepo J, Voshart D, Aguillon D, Villegas A, Castano D, et al.
Front Aging Neurosci
. 2020 Dec;
12:587989.
PMID: 33281599
Evidence suggests that extracellular vesicles (EVs) act as mediators and biomarkers of neurodegenerative diseases. Two distinct forms of Alzheimer disease (AD) are known: a late-onset sporadic form (SAD) and an...
10.
Sabogal-Guaqueta A, Posada-Duque R, Cortes N, Arias-Londono J, Cardona-Gomez G
Neuropharmacology
. 2018 Apr;
135:555-571.
PMID: 29680773
Phospholipid alterations in the brain are associated with progressive neurodegeneration and cognitive impairment after acute and chronic injuries. Various types of treatments have been evaluated for their abilities to block...