Rachel Van Drunen
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Explore the profile of Rachel Van Drunen including associated specialties, affiliations and a list of published articles.
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10
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89
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Recent Articles
1.
Dandavate V, Bolshette N, Van Drunen R, Manella G, Bueno-Levy H, Zerbib M, et al.
Cell Metab
. 2024 Aug;
36(9):2038-2053.e5.
PMID: 39106859
The transcriptional response to hypoxia is temporally regulated, yet the molecular underpinnings and physiological implications are unknown. We examined the roles of hepatic Bmal1 and Hif1α in the circadian response...
2.
Van Drunen R, Dai Y, Wei H, Fekry B, Noori S, Shivshankar S, et al.
Cell Rep
. 2024 Jun;
43(7):114380.
PMID: 38935503
Circadian rhythms are internal biological rhythms driving temporal tissue-specific, metabolic programs. Loss of the circadian transcription factor BMAL1 in the paraventricular nucleus (PVN) of the hypothalamus reveals its importance in...
3.
Gao Z, Santos R, Rupert J, Van Drunen R, Yu Y, Eckel-Mahan K, et al.
Aging Cell
. 2024 Mar;
23(6):e14138.
PMID: 38475941
It has remained unclear how aging of endothelial cells (EC) contributes to pathophysiology of individual organs. Cell senescence results in part from inactivation of telomerase (TERT). Here, we analyzed mice...
4.
Van Drunen R, Eckel-Mahan K
Front Neural Circuits
. 2023 Feb;
16:1059229.
PMID: 36741032
The circadian clock plays a prominent role in neurons during development and throughout aging. This review covers topics pertinent to the role of 24-h rhythms in neuronal development and function,...
5.
Sopariwala D, Rios A, Pei G, Roy A, Tomaz da Silva M, Thi Thu Nguyen H, et al.
FASEB J
. 2022 Dec;
37(2):e22727.
PMID: 36583689
Transcriptional determinants in the skeletal muscle that govern exercise capacity, while poorly defined, could provide molecular insights into how exercise improves fitness. Here, we have elucidated the role of nuclear...
6.
Fekry B, Ribas-Latre A, Van Drunen R, Santos R, Shivshankar S, Dai Y, et al.
FASEB J
. 2022 Aug;
36(9):e22482.
PMID: 35947136
Hepatocellular carcinoma (HCC) is a leading cause of cancer deaths, and the most common primary liver malignancy to present in the clinic. With the exception of liver transplant, treatment options...
7.
Van Drunen R, Jimenez-Vergara A, Tsai E, Tchen R, Cagle T, Agee A, et al.
ACS Appl Bio Mater
. 2022 Jan;
2(3):975-980.
PMID: 35021387
This work describes for the first time the fabrication and characterization of multicomponent interpenetrating networks composed of collagen I, hyaluronic acid, and poly(ethylene glycol) diacrylate for the 3D culture of...
8.
Van Drunen R, Eckel-Mahan K
Clocks Sleep
. 2021 Mar;
3(1):189-226.
PMID: 33668705
The nearly ubiquitous expression of endogenous 24 h oscillations known as circadian rhythms regulate the timing of physiological functions in the body. These intrinsic rhythms are sensitive to external cues,...
9.
Jimenez-Vergara A, Van Drunen R, Cagle T, Munoz-Pinto D
Sci Rep
. 2020 Nov;
10(1):20734.
PMID: 33244148
Hyaluronic acid (HA) is a highly abundant component in the extracellular matrix (ECM) and a fundamental element to the architecture and the physiology of the central nervous system (CNS). Often,...
10.
Ran Kim E, Xu Y, Cassidy R, Lu Y, Yang Y, Tian J, et al.
Nat Commun
. 2020 Aug;
11(1):3794.
PMID: 32732906
Defective rhythmic metabolism is associated with high-fat high-caloric diet (HFD) feeding, ageing and obesity; however, the neural basis underlying HFD effects on diurnal metabolism remains elusive. Here we show that...