Rachel P L van Swelm
Overview
Explore the profile of Rachel P L van Swelm including associated specialties, affiliations and a list of published articles.
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24
Citations
344
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Recent Articles
1.
Diepeveen L, Stegemann G, Wiegerinck E, Roelofs R, Naber M, Loreal O, et al.
Int J Mol Sci
. 2022 Feb;
23(3).
PMID: 35163276
Hemolysis is known to cause acute kidney injury (AKI). The iron regulatory hormone hepcidin, produced by renal distal tubules, is suggested to exert a renoprotective role during this pathology. We...
2.
van Swelm R, Beurskens S, Dijkman H, Wiegerinck E, Roelofs R, Thevenod F, et al.
Sci Rep
. 2022 Jan;
12(1):1199.
PMID: 35075227
Kidney iron deposition may play a role in the progression of tubulointerstitial injury during chronic kidney disease. Here, we studied the molecular mechanisms of kidney iron loading in experimental focal...
3.
Probst S, Fels J, Scharner B, Wolff N, Roussa E, van Swelm R, et al.
Arch Toxicol
. 2021 Jun;
95(8):2719-2735.
PMID: 34181029
The liver hormone hepcidin regulates systemic iron homeostasis. Hepcidin is also expressed by the kidney, but exclusively in distal nephron segments. Several studies suggest hepcidin protects against kidney damage involving...
4.
McKay A, Peeling P, Pyne D, Tee N, Welveart M, Heikura I, et al.
Int J Sport Nutr Exerc Metab
. 2020 Dec;
31(2):101-108.
PMID: 33383570
This study implemented a 2-week high carbohydrate (CHO) diet intended to maximize CHO oxidation rates and examined the iron-regulatory response to a 26-km race walking effort. Twenty international-level, male race...
5.
Vreugdenhil M, Akkermans M, van Swelm R, Laarakkers C, Houdijk E, Bakker B, et al.
Pediatr Hematol Oncol
. 2020 Oct;
38(2):108-123.
PMID: 33026897
Chronic low-grade inflammation in type 1 diabetes (T1D) might increase hepcidin synthesis, possibly resulting in functional iron deficiency (FID). We hypothesized that in T1D children with FID, hepcidin concentrations are...
6.
McKay A, Heikura I, Burke L, Peeling P, Pyne D, van Swelm R, et al.
Int J Sport Nutr Exerc Metab
. 2019 Oct;
30(1):34-41.
PMID: 31629353
Sleeping with low carbohydrate (CHO) availability is a dietary strategy that may enhance training adaptation. However, the impact on an athlete's health is unclear. This study quantified the effect of...
7.
van Swelm R, Wetzels J, Swinkels D
Nat Rev Nephrol
. 2019 Sep;
16(2):77-98.
PMID: 31554933
Iron is an essential element that is indispensable for life. The delicate physiological body iron balance is maintained by both systemic and cellular regulatory mechanisms. The iron-regulatory hormone hepcidin assures...
8.
Diepeveen L, Laarakkers C, Peters H, van Herwaarden A, Groenewoud H, IntHout J, et al.
Pharmaceuticals (Basel)
. 2019 Aug;
12(3).
PMID: 31450766
Peptide hormone hepcidin regulates systemic iron metabolism and has been described to be partially bound to α2-macroglobulin and albumin in blood. However, the reported degree of hepcidin protein binding varies...
9.
McKay A, Peeling P, Pyne D, Welvaert M, Tee N, Leckey J, et al.
J Sci Med Sport
. 2019 Jan;
22(6):635-640.
PMID: 30630742
Objectives: Adhering to a low carbohydrate (CHO) high fat (LCHF) diet can alter markers of iron metabolism in endurance athletes. This investigation examined the re-introduction of CHO prior to, and...
10.
van Raaij S, Rennings A, Biemond B, Schols S, Wiegerinck E, Roelofs H, et al.
Am J Physiol Renal Physiol
. 2019 Jan;
316(3):F606-F614.
PMID: 30623722
In physiological conditions, circulating iron can be filtered by the glomerulus and is almost completely reabsorbed by the tubular epithelium to prevent urinary iron wasting. Increased urinary iron concentrations have...