Rachel Milne
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Explore the profile of Rachel Milne including associated specialties, affiliations and a list of published articles.
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20
Citations
128
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Recent Articles
1.
Wall R, MacGowan S, Hallyburton I, Syed A, Ajay Castro S, Dey G, et al.
mBio
. 2024 Aug;
15(10):e0170824.
PMID: 39191404
Importance: An increase in treatment failures for malaria highlights an urgent need for new tools to understand and minimize the spread of drug resistance. We describe the development of a...
2.
Hernandez R, Hearn J, Bhoopalan V, Hamzeh A, Kwong K, Diamand K, et al.
J Allergy Clin Immunol
. 2024 May;
154(3):767-777.
PMID: 38710235
Background: LCP1 encodes L-plastin, an actin-bundling protein primarily expressed in hematopoietic cells. In mouse and fish models, LCP1 deficiency has been shown to result in hematologic and immune defects. Objective:...
3.
Bopp S, Pasaje C, Summers R, Magistrado-Coxen P, Schindler K, Corpas-Lopez V, et al.
Nat Commun
. 2023 Mar;
14(1):1455.
PMID: 36927839
Identifying how small molecules act to kill malaria parasites can lead to new "chemically validated" targets. By pressuring Plasmodium falciparum asexual blood stage parasites with three novel structurally-unrelated antimalarial compounds...
4.
Smith R, Milne R, Corpas Lopez V, Wiedemar N, Dey G, Syed A, et al.
STAR Protoc
. 2023 Jan;
4(1):102002.
PMID: 36609153
Here, we provide a protocol using chemical pulldown combined with mass spectrometry (LC-MS/MS) to identify drug targets in Plasmodium falciparum. This approach works upon the principle that a resin-bound inhibitor...
5.
Navidpour L, Lima M, Milne R, Wyllie S, Hadj-Esfandiari N, Choudhary M, et al.
Antimicrob Agents Chemother
. 2022 Oct;
66(11):e0058322.
PMID: 36286539
The antileishmanial activity of a series of ()-2-(heteroarylmethylene)-3(2)-benzofuranone derivatives, possessing 5-nitroimidazole or 4-nitroimidazole moieties, was investigated against Leishmania major promastigotes and some analogues exhibited prominent activities. Compounds with IC values...
6.
Milne R, Wiedemar N, Corpas-Lopez V, Moynihan E, Wall R, Dawson A, et al.
ACS Infect Dis
. 2022 Aug;
8(9):1962-1974.
PMID: 36037410
There is a pressing need for new medicines to prevent and treat malaria. Most antimalarial drug discovery is reliant upon phenotypic screening. However, with the development of improved target validation...
7.
Tamaki F, Fisher F, Milne R, Sanchez-Roman Teran F, Wiedemar N, Wrobel K, et al.
Antimicrob Agents Chemother
. 2022 Jun;
66(6):e0023722.
PMID: 35647647
Artemisinin-based combination therapies have been crucial in driving down the global burden of malaria, the world's largest parasitic killer. However, their efficacy is now threatened by the emergence of resistance...
8.
Smith A, Wall R, Patterson S, Rowan T, Rico Vidal E, Stojanovski L, et al.
J Med Chem
. 2022 Mar;
65(7):5606-5624.
PMID: 35303411
African animal trypanosomiasis or nagana, caused principally by infection of the protozoan parasites and is a major problem in cattle and other livestocks in sub-Saharan Africa. Current treatments are threatened...
9.
Lima M, Tulloch L, Corpas-Lopez V, Carvalho S, Wall R, Milne R, et al.
Antimicrob Agents Chemother
. 2021 Oct;
66(1):e0153521.
PMID: 34606338
Phenotypic screening identified an arylsulfonamide compound with activity against Trypanosoma cruzi, the causative agent of Chagas' disease. Comprehensive mode of action studies revealed that this compound primarily targets the T....
10.
Pedron J, Boudot C, Brossas J, Pinault E, Bourgeade-Delmas S, Sournia-Saquet A, et al.
ACS Med Chem Lett
. 2020 Apr;
11(4):464-472.
PMID: 32292551
An antikinetoplastid pharmacomodulation study was conducted at position 6 of the 8-nitroquinolin-2(1)-one pharmacophore. Fifteen new derivatives were synthesized and evaluated against , , and , in parallel with a cytotoxicity...