Rachel Huddart
Overview
Explore the profile of Rachel Huddart including associated specialties, affiliations and a list of published articles.
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Articles
18
Citations
945
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0
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Recent Articles
1.
Duarte J, Thomas C, Lee C, Huddart R, Agundez J, Baye J, et al.
Clin Pharmacol Ther
. 2024 Jul;
116(4):939-947.
PMID: 38951961
Beta-blockers are widely used medications for a variety of indications, including heart failure, myocardial infarction, cardiac arrhythmias, and hypertension. Genetic variability in pharmacokinetic (e.g., CYP2D6) and pharmacodynamic (e.g., ADRB1, ADRB2,...
2.
Miller E, Norwood C, Giles J, Huddart R, Karnes J, Whirl-Carrillo M, et al.
Pharmacogenet Genomics
. 2022 Feb;
32(3):117-124.
PMID: 35102073
No abstract available.
3.
Whirl-Carrillo M, Huddart R, Gong L, Sangkuhl K, Thorn C, Whaley R, et al.
Clin Pharmacol Ther
. 2021 Jul;
110(3):563-572.
PMID: 34216021
Clinical annotations are one of the most popular resources available on the Pharmacogenomics Knowledgebase (PharmGKB). Each clinical annotation summarizes the association between variant-drug pairs, shows relevant findings from the curated...
4.
Mcdermott J, Wolf J, Hoshitsuki K, Huddart R, Caudle K, Whirl-Carrillo M, et al.
Clin Pharmacol Ther
. 2021 May;
111(2):366-372.
PMID: 34032273
Aminoglycosides are widely used antibiotics with notable side effects, such as nephrotoxicity, vestibulotoxicity, and sensorineural hearing loss (cochleotoxicity). MT-RNR1 is a gene that encodes the 12s rRNA subunit and is...
5.
Crews K, Monte A, Huddart R, Caudle K, Kharasch E, Gaedigk A, et al.
Clin Pharmacol Ther
. 2021 Jan;
110(4):888-896.
PMID: 33387367
Opioids are mainly used to treat both acute and chronic pain. Several opioids are metabolized to some extent by CYP2D6 (codeine, tramadol, hydrocodone, oxycodone, and methadone). Polymorphisms in CYP2D6 have...
6.
Huddart R, Whirl-Carrillo M, Altman R, Klein T
Clin Pharmacol Ther
. 2020 Sep;
109(1):116-122.
PMID: 32978778
Pharmacogenomics (PGx) is a key area of precision medicine, which is already being implemented in some health systems and may help guide clinicians toward effective therapies for individual patients. Over...
7.
Karnes J, Rettie A, Somogyi A, Huddart R, Fohner A, Formea C, et al.
Clin Pharmacol Ther
. 2020 Aug;
109(2):302-309.
PMID: 32779747
Phenytoin is an antiepileptic drug with a narrow therapeutic index and large interpatient pharmacokinetic variability, partly due to genetic variation in CYP2C9. Furthermore, the variant allele HLA-B*15:02 is associated with...
8.
Huddart R, Gong L, Sangkuhl K, Thorn C, Whirl-Carrillo M, Caudle K, et al.
Pharmacol Res
. 2020 May;
158:104838.
PMID: 32407955
No abstract available.
9.
Huddart R, Hicks J, Ramsey L, Strawn J, Smith D, Babilonia M, et al.
Pharmacogenet Genomics
. 2019 Dec;
30(2):26-33.
PMID: 31851125
No abstract available.
10.
Lever J, Barbarino J, Gong L, Huddart R, Sangkuhl K, Whaley R, et al.
Pac Symp Biocomput
. 2019 Dec;
25:611-622.
PMID: 31797632
Precision medicine tailors treatment to individuals personal data including differences in their genome. The Pharmacogenomics Knowledgebase (PharmGKB) provides highly curated information on the effect of genetic variation on drug response...