Rachael Kenworthy
Overview
Explore the profile of Rachael Kenworthy including associated specialties, affiliations and a list of published articles.
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Articles
7
Citations
189
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Recent Articles
1.
Carnevale K, Muroski M, Vakil P, Foley M, Laufersky G, Kenworthy R, et al.
Bioconjug Chem
. 2018 Sep;
29(10):3273-3284.
PMID: 30240193
Research over the past decade has identified several of the key limiting features of multidrug resistance (MDR) in cancer therapy applications, such as evolving glycoprotein receptors at the surface of...
2.
Kenworthy R, Bosco D, deLigio J, Zorio D
Cancer Biol Ther
. 2017 Dec;
19(3):181-187.
PMID: 29261027
Multidrug resistance (MDR) represents a major hindrance to the efficacy of cancer chemotherapeutics. While surgical resection, radiation, and chemotherapy can be used to reduce tumor size, the subsequent appearance of...
3.
Bosco D, Kenworthy R, Zorio D, Sang Q
PLoS One
. 2015 Jun;
10(6):e0128511.
PMID: 26029917
Human mesenchymal stem cell (hMSC) resistance to the apoptotic effects of chemotherapeutic drugs has been of major interest, as these cells can confer this resistance to tumor microenvironments. However, the...
4.
Yang W, Roy S, Phrathep B, Rengert Z, Kenworthy R, Zorio D, et al.
J Med Chem
. 2011 Nov;
54(24):8501-16.
PMID: 22050291
We describe a family of hybrid compounds for the most efficient light-activated double-strand (ds) DNA cleavage known to date. This family represents the second generation of "switchable" molecular systems for...
5.
Short-hairpin RNAs delivered by lentiviral vector transduction trigger RIG-I-mediated IFN activation
Kenworthy R, Lambert D, Yang F, Wang N, Chen Z, Zhu H, et al.
Nucleic Acids Res
. 2009 Sep;
37(19):6587-99.
PMID: 19729514
Activation of the type I interferon (IFN) pathway by small interfering RNA (siRNA) is a major contributor to the off-target effects of RNA interference in mammalian cells. While IFN induction...
6.
Yang F, Robotham J, Nelson H, Irsigler A, Kenworthy R, Tang H
J Virol
. 2008 Apr;
82(11):5269-78.
PMID: 18385230
Cyclosporine (CsA) and its derivatives potently suppress hepatitis C virus (HCV) replication. Recently, CsA-resistant HCV replicons have been identified in vitro. We examined the dependence of the wild-type and CsA-resistant...
7.
Liu Z, Kenworthy R, Green C, Tang H
Exp Cell Res
. 2007 Sep;
313(17):3743-54.
PMID: 17822697
RNA helicase A (RHA) is a member of the DEAH-box family of DNA/RNA helicases involved in multiple cellular processes and the life cycles of many viruses. The subcellular localization of...