R Sinervirta
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Explore the profile of R Sinervirta including associated specialties, affiliations and a list of published articles.
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32
Citations
233
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Recent Articles
1.
Hyvonen M, Sinervirta R, Keinanen T, Fashe T, Grigorenko N, Khomutov A, et al.
Pancreatology
. 2010 May;
10(2-3):208-21.
PMID: 20453551
Background/aims: Polyamines are ubiquitous organic cations essential for cellular proliferation and tissue integrity. We have previously shown that pancreatic polyamine depletion in rats overexpressing the catabolic enzyme, spermidine/spermine N(1)-acetyltransferase (SSAT),...
2.
Merentie M, Uimari A, Pietila M, Sinervirta R, Keinanen T, Vepsalainen J, et al.
Amino Acids
. 2007 Apr;
33(2):323-30.
PMID: 17410333
The markers of oxidative stress and inflammation were studied in acute pancreatitis in transgenic rats exhibiting activated polyamine catabolism. In addition, the effect of bismethylspermine (Me(2)Spm) pretreatment, preventing pancreatitis in...
3.
Rasanen T, Alhonen L, Sinervirta R, Uimari A, Kaasinen K, Keinanen T, et al.
Scand J Gastroenterol
. 2003 Aug;
38(7):787-93.
PMID: 12889567
Background: The male antifertility agent gossypol has been reported to induce spermidine/spermine N1-acetyltransferase (SSAT) in canine prostate cells. As SSAT is the rate-controlling enzyme in the catabolism of the polyamines...
4.
Alhonen L, Parkkinen J, Keinanen T, Sinervirta R, Herzig K, Janne J
Proc Natl Acad Sci U S A
. 2000 Jul;
97(15):8290-5.
PMID: 10880565
Polyamines are required for optimal growth and function of cells. Regulation of their cellular homeostasis is therefore tightly controlled. The key regulatory enzyme for polyamine catabolism is the spermidine/spermine N(1)-acetyltransferase...
5.
Lukkarinen J, Kauppinen R, Grohn O, Oja J, Sinervirta R, Jarvinen A, et al.
Eur J Neurosci
. 1998 Sep;
10(6):2046-55.
PMID: 9753092
Nuclear magnetic resonance imaging (MRI) was used to study dynamics of maturation and the size of ischaemic stroke lesions in rats with greatly increased activity of ornithine decarboxylase (ODC). Syngenic...
6.
Korhonen V, Tolvanen M, Hyttinen J, Uusi-Oukari M, Sinervirta R, Alhonen L, et al.
Eur J Biochem
. 1997 Apr;
245(2):482-9.
PMID: 9151983
We have generated several transgenic mouse lines and rabbits expressing efficiently (up to 0.3 mg/ml in mice and up to 0.5 mg/ml in rabbits) human erythropoietin in their milk as...
7.
Lukkarinen J, Grohn O, Sinervirta R, Jarvinen A, Kauppinen R, Janne J, et al.
Stroke
. 1997 Mar;
28(3):639-45.
PMID: 9056624
Background And Purpose: Cerebral ischemia causes activation of ornithine decarboxylase (ODC) gene and subsequent accumulation of putrescine, which might either directly or indirectly affect the outcome of cerebral infarct. We...
8.
Alhonen L, Heikkinen S, Sinervirta R, Halmekyto M, Alakuijala P, Janne J
Biochem J
. 1996 Mar;
314 ( Pt 2):405-8.
PMID: 8670048
We have generated a transgenic mouse line harbouring the human ornithine decarboxylase gene under the control of mouse metallothionein I promoter. Even in the absence of an exposure to heavy...
9.
Janne J, Hyttinen J, Peura T, Tolvanen M, Alhonen L, Sinervirta R, et al.
Int J Biochem
. 1994 Jul;
26(7):859-70.
PMID: 8063010
1. Although many human therapeutic proteins are currently produced in microbial fermentors using recombinant DNA techniques, it is obvious that microbial processing is not suitable for a large number of...
10.
Hyttinen J, Peura T, Tolvanen M, Aalto J, Alhonen L, Sinervirta R, et al.
Biotechnology (N Y)
. 1994 Jun;
12(6):606-8.
PMID: 7764950
We have generated a transgenic calf from in vitro produced bovine embryos which had undergone transgene analysis and sexing prior to the embryo transfer. Bovine oocytes were isolated from slaughter-house-derived...