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R Scott Harris

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Articles 76
Citations 1667
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Recent Articles
1.
Flume P, Harris R, Paz-Diaz H, Ahluwalia N, Higgins M, Campbell D, et al.
J Cyst Fibros . 2022 Dec; 22(3):464-470. PMID: 36581484
Background: Study 661-110 (EXTEND) is a phase 3, open-label, three-part rollover study designed to assess the long-term safety and efficacy of tezacaftor/ivacaftor (TEZ/IVA) in participants aged ≥12 years homozygous for...
2.
Winkler T, Kohli P, Kelly V, Kehl E, Witkin A, Rodriguez-Lopez J, et al.
Respir Res . 2022 Dec; 23(1):325. PMID: 36457013
Background: Without aggressive treatment, pulmonary arterial hypertension (PAH) has a 5-year mortality of approximately 40%. A patient's response to vasodilators at diagnosis impacts the therapeutic options and prognosis. We hypothesized...
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Sawicki G, Chilvers M, McNamara J, Naehrlich L, Saunders C, Sermet-Gaudelus I, et al.
J Cyst Fibros . 2022 Feb; 21(4):675-683. PMID: 35190292
Background: Two previous Phase 3 studies ("parent studies") showed that tezacaftor/ivacaftor was generally safe and efficacious for up to 24 weeks in children 6 through 11 years of age with...
5.
Corleis B, Cho J, Gates S, Linder A, Dickey A, Lisanti-Park A, et al.
Am J Respir Cell Mol Biol . 2021 Jun; 65(5):513-520. PMID: 34166603
Smoking and human immunodeficiency virus 1 (HIV-1) infection are risk factors for chronic obstructive pulmonary disease (COPD), which is among the most common comorbid conditions in people living with HIV-1....
6.
Alladina J, Levy S, Cho J, Brait K, Rao S, Camacho A, et al.
Am J Respir Crit Care Med . 2021 Jan; 203(10):1257-1265. PMID: 33400890
Standard physiologic assessments of extubation readiness in patients with acute hypoxemic respiratory failure (AHRF) may not reflect lung injury resolution and could adversely affect clinical decision-making and patient outcomes. We...
7.
Kuo Y, Harris R, Hess D, Dieffenbach P, Choi A, Fredenburgh L, et al.
Crit Care Explor . 2020 Dec; 2(12):e0286. PMID: 33283194
Low-dose inhaled carbon monoxide is a novel therapeutic under investigation in acute respiratory distress syndrome. The Coburn-Forster-Kane equation is a well-validated model of carbon monoxide uptake that can accurately predict...
8.
Davies J, Sermet-Gaudelus I, Naehrlich L, Harris R, Campbell D, Ahluwalia N, et al.
J Cyst Fibros . 2020 Sep; 20(1):68-77. PMID: 32967799
Background: The CFTR modulator tezacaftor/ivacaftor was efficacious and generally safe and well tolerated in Phase 3 studies in participants ≥12 years of age with cystic fibrosis (CF) homozygous for the...
9.
Mendoza D, Kohli P, Nance J, Singh R, Cho J, Griffith J, et al.
Ann Transl Med . 2020 Aug; 8(14):862. PMID: 32793706
Background: Computed tomography (CT) imaging findings in the lungs in the setting of an acute allergic response and following bronchoalveolar lavage (BAL) are not well established. Our goals are to...
10.
Kohli P, Kelly V, Hibbert K, Corleis B, Kone M, Cho J, et al.
J Nucl Med . 2020 Aug; 62(3):405-411. PMID: 32764123
Chronic obstructive pulmonary disease (COPD) is the most common noninfectious pulmonary disease among people living with HIV, independent of smoking. However, the cause for this enhanced susceptibility remains unclear, and...