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R Paulmurugan

Explore the profile of R Paulmurugan including associated specialties, affiliations and a list of published articles. Areas
Snapshot
Articles 18
Citations 426
Followers 0
Related Specialties
Microbiology
Toxicology
Science
Top 10 Co-Authors
S S Gambhir
T V Sekar
P Padmanabhan
F Berger
K M Ramkumar
S Kamatchiammal
N Jothikumar
E Bhakkiyalakshmi
S Ray
N Suganya
Published In
Gene Ther
Proc Natl Acad Sci U S A
Appl Environ Microbiol
J Appl Toxicol
Curr Med Chem
Affiliations
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Recent Articles
1.
Syntheses and discovery of a novel class of cinnamic hydroxamates as histone deacetylase inhibitors by multimodality molecular imaging in living subjects
Chan C, Qi J, Smith W, Paranol R, Mazitschek R, West N, et al.
Cancer Res . 2014 Oct; 74(24):7475-86. PMID: 25320008
Histone deacetylases (HDAC) that regulate gene expression are being explored as cancer therapeutic targets. In this study, we focused on HDAC6 based on its ability to inhibit cancerous Hsp90 chaperone...
2.
Proteomic identification of pterostilbene-mediated anticancer activities in HepG2 cells
Suganya N, Bhakkiyalakshmi E, Subin T, Krishnamurthi K, Saravana Devi S, Lau K, et al.
Chem Res Toxicol . 2014 Jun; 27(7):1243-52. PMID: 24936659
In the present study, we attempt to shed light on the underlying molecular mechanism of the anticancer activity of pterostilbene (PTS) in HepG2 cells through the proteomic approach. PTS was...
3.
Quercetin ameliorates tunicamycin-induced endoplasmic reticulum stress in endothelial cells
Suganya N, Bhakkiyalakshmi E, Suriyanarayanan S, Paulmurugan R, Ramkumar K
Cell Prolif . 2014 Mar; 47(3):231-40. PMID: 24666891
Objective: Endothelial dysfunction highlights that it is a potential contributor in the pathogenesis of vascular complications arising from endoplasmic reticulum stress (ER stress) and has been emerging as a main...
4.
The impact of oxidative stress on islet transplantation and monitoring the graft survival by non-invasive imaging
Ramkumar K, Sekar T, Bhakkiyalakshmi E, Foygel K, Rajaguru P, Berger F, et al.
Curr Med Chem . 2013 Jan; 20(9):1127-46. PMID: 23317098
Islet transplantation is an attractive strategy to treat severe diabetic conditions in patients suffering from autoimmune derived diabetes, and it has currently been considered a forefront research arena in diabetes....
5.
Dual-therapeutic reporter genes fusion for enhanced cancer gene therapy and imaging
Sekar T, Foygel K, Willmann J, Paulmurugan R
Gene Ther . 2012 Aug; 20(5):529-37. PMID: 22914496
Two of the successful gene-directed enzyme prodrug therapies include herpes simplex virus-thymidine kinase (HSV1-TK) enzyme-ganciclovir prodrug and the Escherichia coli nitroreductase (NTR) enzyme-CB1954 prodrug strategies; these enzyme-prodrug combinations produce activated...
6.
Noninvasive optical imaging of nitroreductase gene-directed enzyme prodrug therapy system in living animals
Bhaumik S, Sekar T, Depuy J, Klimash J, Paulmurugan R
Gene Ther . 2011 Jul; 19(3):295-302. PMID: 21753794
Gene-directed enzyme prodrug therapy (GDEPT) is a promising and emerging strategy that attempts to limit the systemic toxicity inherent to cancer chemotherapy by means of tumor-targeted delivery and expression of...
7.
Potent, tumor-specific gene expression in an orthotopic hepatoma rat model using a Survivin-targeted, amplifiable adenoviral vector
Ahn B, Ronald J, Kim Y, Katzenberg R, Singh A, Paulmurugan R, et al.
Gene Ther . 2011 Feb; 18(6):606-12. PMID: 21307888
Ideal cancer gene therapies should have high tumor specificity and efficacy, and allow systemic administration to target metastases. We recently developed a bi-directional, two-step transcriptional amplification (TSTA) system driven by...
8.
Indirect imaging of cardiac-specific transgene expression using a bidirectional two-step transcriptional amplification strategy
Chen I, Gheysens O, Ray S, Wang Q, Padmanabhan P, Paulmurugan R, et al.
Gene Ther . 2010 Mar; 17(7):827-38. PMID: 20237511
Transcriptional targeting for cardiac gene therapy is limited by the relatively weak activity of most cardiac-specific promoters. We have developed a bidirectional plasmid vector, which uses a two-step transcriptional amplification...
9.
Molecular imaging of phosphorylation events for drug development
Chan C, Paulmurugan R, Reeves R, Solow-Cordero D, Gambhir S
Mol Imaging Biol . 2008 Dec; 11(3):144-58. PMID: 19048345
Purpose: Protein phosphorylation mediated by protein kinases controls numerous cellular processes. A genetically encoded, generalizable split firefly luciferase (FL)-assisted complementation system was developed for noninvasive monitoring phosphorylation events and efficacies...
10.
RIP1 links inflammatory and growth factor signaling pathways by regulating expression of the EGFR
Ramnarain D, Paulmurugan R, Park S, Mickey B, Asaithamby A, Saha D, et al.
Cell Death Differ . 2007 Nov; 15(2):344-53. PMID: 18007664
There is considerable interest in understanding how inflammatory responses influence cell proliferation and cancer. In this study, we show that the receptor-interacting protein (RIP1), a critical mediator of inflammation and...