R Meldrum Robertson
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Explore the profile of R Meldrum Robertson including associated specialties, affiliations and a list of published articles.
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86
Citations
782
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Recent Articles
1.
Robertson R, Wang Y
J Neurophysiol
. 2024 Dec;
133(1):245-256.
PMID: 39665253
Spreading depolarization (SD) temporarily shuts down neural processing in mammals and insects. Age is a critical factor for predicting the consequences of SD in humans. We investigated the effect of...
2.
Wang Y, Van Dusen R, McGuire C, Andrew R, Robertson R
J Neurophysiol
. 2024 Oct;
132(5):1621-1632.
PMID: 39412568
Spreading depolarization (SD) describes the near-complete depolarization of central nervous system (CNS) neural cells as a consequence of chemical, electrical, or metabolic perturbations. It is well established as the central...
3.
Wang Y, Little A, Aristizabal M, Robertson R
eNeuro
. 2023 Nov;
10(11).
PMID: 37932046
Migratory locusts enter a reversible hypometabolic coma to survive environmental anoxia, wherein the cessation of CNS activity is driven by spreading depolarization (SD). While glycolysis is recognized as a crucial...
4.
Srithiphaphirom P, Wang Y, Aristizabal M, Robertson R
Comp Biochem Physiol A Mol Integr Physiol
. 2023 Sep;
285:111511.
PMID: 37690599
Insects experience different kinds of environmental stresses that can impair neural performance, leading to spreading depolarization (SD) of nerve cells and neural shutdown underlying coma. SD is associated with a...
5.
Robertson R, MacMillan H, Andersen M
Curr Opin Insect Sci
. 2023 May;
58:101055.
PMID: 37201631
Exposure to cold causes insects to enter a chill coma at species-specific temperatures and such temperature sensitivity contributes to geographic distribution and phenology. Coma results from abrupt spreading depolarization (SD)...
6.
Andersen M, Robertson R, MacMillan H
J Exp Biol
. 2022 Dec;
225(24).
PMID: 36477887
Most insects can acclimate to changes in their thermal environment and counteract temperature effects on neuromuscular function. At the critical thermal minimum, a spreading depolarization (SD) event silences central neurons,...
7.
Robertson R, Moyes C
J Exp Biol
. 2022 Jun;
225(11).
PMID: 35673989
Rapid cold hardening (RCH) is a type of phenotypic plasticity that delays the occurrence of chill coma in insects. Chill coma is mediated by a spreading depolarization of neurons and...
8.
Qiu S, Xiao C, Robertson R
Front Physiol
. 2022 May;
13:852919.
PMID: 35530504
Cyclic guanosine monophosphate (cGMP) modulates the speed of recovery from anoxia in adult and mediates hypoxia-related behaviors in larvae. Cyclic nucleotide-gated channels (CNG) and cGMP-activated protein kinase (PKG) are two...
9.
Andrew R, Hartings J, Ayata C, Brennan K, Dawson-Scully K, Farkas E, et al.
Neurocrit Care
. 2022 Mar;
37(Suppl 1):83-101.
PMID: 35257321
Background: When a patient arrives in the emergency department following a stroke, a traumatic brain injury, or sudden cardiac arrest, there is no therapeutic drug available to help protect their...
10.
Andrew R, Farkas E, Hartings J, Brennan K, Herreras O, Muller M, et al.
Neurocrit Care
. 2022 Feb;
37(Suppl 1):11-30.
PMID: 35194729
Background: Within 2 min of severe ischemia, spreading depolarization (SD) propagates like a wave through compromised gray matter of the higher brain. More SDs arise over hours in adjacent tissue,...