R Maschler
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Explore the profile of R Maschler including associated specialties, affiliations and a list of published articles.
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26
Citations
138
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Recent Articles
1.
Steiner V, Knecht R, Bornsen K, Gassmann E, Stone S, Raschdorf F, et al.
Biochemistry
. 1992 Mar;
31(8):2294-8.
PMID: 1540584
Hirudin from the leech Hirudo medicinalis is a most powerful anticoagulant, and many isoforms have been described. In the present work, the primary structure of two hirudins from the leech...
2.
Bichler J, Siebeck M, Maschler R, Pelzer H, Fritz H
Blood Coagul Fibrinolysis
. 1991 Feb;
2(1):129-33.
PMID: 1772980
An enzyme-linked immunosorbent assay (ELISA) was developed for the determination of the thrombin-hirudin complex (TH) in plasma. The test is based on the sandwich principle and uses appropriate antibodies which...
3.
Steiner V, Knecht R, Gruetter M, Raschdorf F, Gassmann E, Maschler R
J Chromatogr
. 1990 Sep;
530(2):273-82.
PMID: 2079503
The isolation and purification of novel hirudins from a crude extract of the leech Hirudinaria manillensis and their analytical characterization are reported. Initial purification by gel permeation chromatography on Sephadex...
4.
Spinner S, Scheffauer F, Maschler R, Stoffler G
Thromb Res
. 1988 Sep;
51(6):617-25.
PMID: 3187968
A catching ELISA has been developed that permits a quantitation of the anticoagulant hirudin in buffer, urine and plasma. In plasma hirudin can be determined in concentrations ranging from 0.2...
5.
Braun N, Bodmer J, Virca G, Maschler R, Bieth J, Schnebli H
Biol Chem Hoppe Seyler
. 1987 Apr;
368(4):299-308.
PMID: 3649242
We have investigated the inhibition of human leukocyte elastase and cathepsin G by recombinant Eglin c under near physiological conditions. The association rate constants k on of Eglin c for...
6.
Dodt J, Machleidt W, Seemuller U, Maschler R, Fritz H
Biol Chem Hoppe Seyler
. 1986 Aug;
367(8):803-11.
PMID: 3768144
A five-step isolation procedure has been developed for the purification of isoforms of hirudin (isohirudins) from whole leeches. The final purification of two thrombin-inhibiting preparations by reversed-phase high-performance liquid chromatography...
7.
Snider G, Stone P, LUCEY E, Breuer R, Calore J, Seshadri T, et al.
Am Rev Respir Dis
. 1985 Dec;
132(6):1155-61.
PMID: 3907441
Eglin-c (Eg-c), a polypeptide with a molecular mass of 8,100 daltons, was purified from the medicinal leech Hirudo medicinalis. The Eg-c was tritiated by reductive methylation for in vitro studies....
8.
Dodt J, Seemuller U, Maschler R, Fritz H
Biol Chem Hoppe Seyler
. 1985 Apr;
366(4):379-85.
PMID: 4026992
Hirudin, the thrombin-specific inhibitor from the leech Hirudo medicinalis, is a single-chain polypeptide (65 amino-acid residues) linked by three disulfide bridges. Localization of the three disulfide bonds could be assigned...
9.
Chang J, Knecht R, Maschler R, Seemuller U
Biol Chem Hoppe Seyler
. 1985 Mar;
366(3):281-6.
PMID: 4005044
The structures of eglin b and eglin c, both potent inhibitors of human neutral granulocytic proteinase elastase and cathepsin G, were compared by micro amino-acid analysis and peptide mapping techniques....
10.
Schnebli H, Seemuller U, Fritz H, Maschler R, Liersch M, Virca G, et al.
Eur J Respir Dis Suppl
. 1985 Jan;
139:66-70.
PMID: 3862612
Eglin c is an elastase/cathepsin G inhibitor from leech Hirudo medicinalis. The gene for this 70 aminoacid peptide was synthesized chemically, cloned and expressed by E. coli. Here we report...