R M Sharpe
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Explore the profile of R M Sharpe including associated specialties, affiliations and a list of published articles.
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209
Citations
2495
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Recent Articles
11.
Bellingham M, McKinnell C, Fowler P, Amezaga M, Zhang Z, Rhind S, et al.
Int J Androl
. 2011 Dec;
35(3):317-29.
PMID: 22150464
Exposure to ubiquitous, environmental chemicals (ECs) has been hypothesized as a cause for declining male reproductive health. Understanding the long-term effects of EC exposure on reproductive health in humans requires...
12.
Auharek S, Avelar G, Lara N, Sharpe R, Franca L
Int J Androl
. 2011 Aug;
34(6 Pt 2):e621-9.
PMID: 21831234
Nitric oxide (NO) is produced via oxidation of l-arginine by nitric oxide synthases (NOSs), and is known as inducible (iNOS), neuronal, endothelial or testis-specific. Suggesting important functions for NOS in...
13.
Welsh M, Moffat L, Belling K, de Franca L, Segatelli T, Saunders P, et al.
Int J Androl
. 2011 Jun;
35(1):25-40.
PMID: 21651570
Testosterone synthesis depends on normal Leydig cell (LC) development, but the mechanisms controlling this development remain unclear. We recently demonstrated that androgen receptor (AR) ablation from a proportion of testicular...
14.
van den Driesche S, Scott H, MacLeod D, Fisken M, Walker M, Sharpe R
Int J Androl
. 2011 Jun;
34(6 Pt 2):e578-86.
PMID: 21631528
Experimental animal studies show that measurement of anogenital distance (AGD) and/or penis length may provide lifelong 'read-outs' of foetal androgen exposure during the masculinization programming window (MPW). However, variation in...
15.
Jobling M, Hutchison G, van den Driesche S, Sharpe R
Int J Androl
. 2011 Feb;
34(5 Pt 2):e386-96.
PMID: 21332505
Environmental factors are implicated in increased incidence of human testicular germ-cell cancer (TGCC). TGCC has foetal origins and may be one component of a testicular dysgenesis syndrome (TDS). Certain phthalates...
16.
Rhind S, Kyle C, Mackie C, McDonald L, Zhang Z, Duff E, et al.
J Environ Monit
. 2010 Aug;
12(8):1582-93.
PMID: 20676422
Liver concentrations of selected pollutant classes were determined in groups of sheep fetuses and their dams, at 55 (Experiment 1) and 110 (Experiment 2) days of gestation (term = 145...
17.
Rhind S, Evans N, Bellingham M, Sharpe R, Cotinot C, Mandon-Pepin B, et al.
Animal
. 2010 Jun;
4(7):1227-1239.
PMID: 20582145
Anthropogenic pollutants comprise a wide range of synthetic organic compounds and heavy metals, which are dispersed throughout the environment, usually at low concentrations. Exposure of ruminants, as for all other...
18.
Bellingham M, Fowler P, Amezaga M, Whitelaw C, Rhind S, Cotinot C, et al.
J Neuroendocrinol
. 2010 Mar;
22(6):527-33.
PMID: 20236231
Animals and humans are chronically exposed to endocrine disrupting chemicals (EDCs) that are ubiquitous in the environment. There are strong circumstantial links between environmental EDC exposure and both declining human/wildlife...
19.
MacLeod D, Sharpe R, Welsh M, Fisken M, Scott H, Hutchison G, et al.
Int J Androl
. 2009 Dec;
33(2):279-87.
PMID: 20002220
We have shown previously that deficient androgen action within a masculinization programming window (MPW; e15.5-e18.5 in rats) is important in the origin of male reproductive disorders and in programming male...
20.
Mitchell R, Saunders P, Sharpe R, Kelnar C, Wallace W
Endocr Dev
. 2009 Mar;
15:101-134.
PMID: 19293606
Infertility in the male is a potential complication of childhood cancer treatment for long-term survivors. The risk is dependent primarily on the treatment used, but also on the underlying disease....