R M Schiffelers
Overview
Explore the profile of R M Schiffelers including associated specialties, affiliations and a list of published articles.
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Articles
26
Citations
573
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0
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Recent Articles
1.
Labonia M, Estape Senti M, van der Kraak P, Brans M, Dokter I, Streef T, et al.
J Control Release
. 2024 Apr;
369:734-745.
PMID: 38604385
Despite research efforts being made towards preserving (or even regenerating) heart tissue after an ischemic event, there is a lack of resources in current clinical treatment modalities for patients with...
2.
Swart L, Koekman C, Seinen C, Issa H, Rasouli M, Schiffelers R, et al.
Int J Pharm
. 2022 Apr;
620:121741.
PMID: 35421533
Targeted delivery of nucleic acids is gaining momentum due to improved efficacy, selectivity, increased circulation time and enhanced tissue retention in target cells. Using nucleic acid-based therapies previously undruggable targets...
3.
Huisjes R, Satchwell T, Verhagen L, Schiffelers R, van Solinge W, Toye A, et al.
Int J Lab Hematol
. 2018 May;
40(4):e74-e77.
PMID: 29746727
No abstract available.
4.
Jiang L, Vader P, Schiffelers R
Gene Ther
. 2017 Feb;
24(3):157-166.
PMID: 28140387
Nucleic acid-based drugs offer a potentially effective tool for treatment of a variety of diseases, including cancer, cardiovascular diseases, neurological disorders and infectious diseases. However, clinical applications are hindered by...
5.
PEGylated and targeted extracellular vesicles display enhanced cell specificity and circulation time
Kooijmans S, Fliervoet L, van der Meel R, Fens M, Heijnen H, van Bergen En Henegouwen P, et al.
J Control Release
. 2016 Jan;
224:77-85.
PMID: 26773767
Extracellular vesicles (EVs) are increasingly being recognized as candidate drug delivery systems due to their ability to functionally transfer biological cargo between cells. However, the therapeutic applicability of EVs may...
6.
Nieuwenhuizen L, Schutgens R, Coeleveld K, Mastbergen S, Schiffelers R, Roosendaal G, et al.
Haemophilia
. 2015 Jul;
22(1):152-9.
PMID: 26189554
Introduction And Aim: Joint bleeding results in blood-induced arthropathy. We investigate whether a joint bleed alters protease-activated receptor (PAR) expression, and whether treatment with small interfering RNA (siRNA) targeted against...
7.
van der Aa L, Vader P, Storm G, Schiffelers R, Engbersen J
J Control Release
. 2014 Aug;
195:11-20.
PMID: 25135792
In the development of potent polymeric gene carriers for gene therapy, a good interaction between the polymer and the nucleotide is indispensable to form small and stable polyplexes. Polymers with...
8.
van der Meel R, Krawczyk-Durka M, van Solinge W, Schiffelers R
Int J Lab Hematol
. 2014 Apr;
36(3):244-53.
PMID: 24750670
The majority, if not all, of human cell types secrete extracellular vesicles (EVs) into their environment, at least partly as a means of intercellular communication. These secreted vesicles can be...
9.
Coimbra M, Rijcken C, Stigter M, Hennink W, Storm G, Schiffelers R
J Control Release
. 2012 Oct;
163(3):361-7.
PMID: 23041274
In the current study, core-crosslinked polymeric micelles (DEX-PMs) loaded with three different DEX derivatives designed to display different drug release kinetics, were evaluated for cancer therapy and compared to another...
10.
Vader P, van der Aa L, Storm G, Schiffelers R, Engbersen J
Curr Top Med Chem
. 2011 Dec;
12(2):108-19.
PMID: 22196278
RNA interference is a technique to induce sequence-specific gene silencing, but is hampered by inefficient delivery of its mediator, short interfering RNA, into target cells. This review describes recent advances...