R M Liskay
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Explore the profile of R M Liskay including associated specialties, affiliations and a list of published articles.
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69
Citations
3150
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Recent Articles
1.
Fischer J, Miller A, Shibata D, Liskay R
Oncogene
. 2011 Sep;
31(16):2028-38.
PMID: 21892206
APC is considered a gatekeeper for colorectal cancer (CRC). Cells with heterozygous APC mutations have altered expression profiles suggesting that the first APC hit may help set the stage for...
2.
Gutmann D, Winkeler E, Kabbarah O, Hedrick N, Dudley S, Goodfellow P, et al.
Oncogene
. 2003 Jul;
22(29):4581-5.
PMID: 12881715
Defects in DNA mismatch repair (MMR) have been implicated in the genesis of a diverse set of human cancers. Recent studies have suggested that one of the targets of MMR...
3.
Qin J, Baker S, Te Riele H, Liskay R, Arnheim N
J Hered
. 2002 Aug;
93(3):201-5.
PMID: 12195036
Meiotic recombination was studied in DNA mismatch repair (MMR)-deficient mice using a strain carrying a Pms2 knockout mutation. Using single-sperm typing, recombination was analyzed over five intervals on four chromosomes...
4.
Tran P, Simon J, Liskay R
Proc Natl Acad Sci U S A
. 2001 Aug;
98(17):9760-5.
PMID: 11481425
Previously, we reported evidence suggesting that Saccharomyces cerevisiae MutLalpha, composed of Mlh1p and Pms1p, was a functional member of the gyrase b/Hsp90/MutL (GHL) dimeric ATPase superfamily characterized by highly conserved...
5.
Xu X, Narayanan L, Dunklee B, Liskay R, Glazer P
Cancer Res
. 2001 Apr;
61(9):3775-80.
PMID: 11325851
DNA mismatch repair (MMR) has been shown to play a role in the cytotoxicity of ionizing radiation (IR), as cell lines established from MMR-deficient mice exhibit higher clonogenic survival after...
6.
Makhani N, Liskay R, Jirik F
Oncogene
. 2001 Apr;
20(5):619-25.
PMID: 11313994
Mutations in DNA mismatch repair (MMR) genes are associated with increased genomic instability and susceptibility to cancer. Mice rendered deficient in either Mlh1 or Pms2 as a result of gene...
7.
Bowers J, Tran P, Joshi A, Liskay R, Alani E
J Mol Biol
. 2001 Mar;
306(5):957-68.
PMID: 11237611
In the yeast Saccharomyces cerevisiae, mismatch repair (MMR) is initiated by the binding of heterodimeric MutS homolog (MSH) complexes to mismatches that include single nucleotide and loop insertion/deletion mispairs. In...
8.
Zeng M, Narayanan L, Xu X, Prolla T, Liskay R, Glazer P
Cancer Res
. 2000 Sep;
60(17):4889-93.
PMID: 10987303
The cytotoxicity of ionizing radiation (IR) has been associated with both the p53 pathway and with DNA mismatch repair (MMR). p53 mediates cell cycle arrest and apoptosis in response to...
9.
Bowers J, Tran P, Liskay R, Alani E
J Mol Biol
. 2000 Sep;
302(2):327-38.
PMID: 10970737
The yeast MSH2-MSH6 complex is required to repair both base-pair and single base insertion/deletion mismatches. MSH2-MSH6 binds to mismatch substrates and displays an ATPase activity that is modulated by mispairs...
10.
Tran P, Liskay R
Mol Cell Biol
. 2000 Aug;
20(17):6390-8.
PMID: 10938116
Saccharomyces cerevisiae MutL homologues Mlh1p and Pms1p form a heterodimer, termed MutLalpha, that is required for DNA mismatch repair after mismatch binding by MutS homologues. Recent sequence and structural studies...