R M Kato
Overview
Explore the profile of R M Kato including associated specialties, affiliations and a list of published articles.
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Articles
12
Citations
565
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Recent Articles
1.
Kang S, Wahl M, Chu J, Kitaura J, Kawakami Y, Kato R, et al.
EMBO J
. 2001 Oct;
20(20):5692-702.
PMID: 11598012
Mutations in Bruton's tyrosine kinase (Btk) result in X-linked agammaglobulinemia (XLA) in humans and X-linked immunodeficiency (xid) in mice. While targeted disruption of the protein kinase C-beta (PKCbeta) gene in...
2.
Guo B, Kato R, Garcia-Lloret M, Wahl M, Rawlings D
Immunity
. 2000 Sep;
13(2):243-53.
PMID: 10981967
Pre-B cell receptor (pre-BCR) expression is critical for B lineage development. The signaling events initiated by the pre-BCR, however, remain poorly defined. We demonstrate that lipid rafts are the major...
3.
Kawakami Y, Kitaura J, Satterthwaite A, Kato R, Asai K, Hartman S, et al.
J Immunol
. 2000 Jul;
165(3):1210-9.
PMID: 10903718
Protein-tyrosine kinases play crucial roles in mast cell activation through the high-affinity IgE receptor (FcepsilonRI). In this study, we have made the following observations on growth properties and FcepsilonRI-mediated signal...
4.
Goldman F, Gilman A, Hollenback C, Kato R, Premack B, Rawlings D
Blood
. 2000 May;
95(11):3460-6.
PMID: 10828029
Hydroxychloroquine (HCQ), a lysosomotropic amine, is an immunosuppressive agent presently being evaluated in bone marrow transplant patients to treat graft-versus-host disease. While its immunosuppressive properties have been attributed primarily to...
5.
Gordon M, Kato R, Lansigan F, Thompson A, Wall R, Rawlings D
Proc Natl Acad Sci U S A
. 2000 May;
97(10):5504-9.
PMID: 10792036
Chronic lymphocytic leukemia (CLL) B cells characteristically exhibit low or undetectable surface B cell receptor (BCR) and diminished responses to BCR-mediated signaling. These features suggest that CLL cells may have...
6.
Nisitani S, Kato R, Rawlings D, Witte O, Wahl M
Proc Natl Acad Sci U S A
. 1999 Mar;
96(5):2221-6.
PMID: 10051622
Bruton's tyrosine kinase (Btk) is a critical transducer of signals originating from the B cell antigen receptor (BCR). Dosage, sequential phosphorylation, and protein interactions are interdependent mechanisms influencing Btk function....
7.
Fluckiger A, Li Z, Kato R, Wahl M, Ochs H, Longnecker R, et al.
EMBO J
. 1998 Jun;
17(7):1973-85.
PMID: 9524120
Bruton's tyrosine kinase (Btk) is essential for B-lineage development and represents an emerging family of non-receptor tyrosine kinases implicated in signal transduction events initiated by a range of cell surface...
8.
Li T, Rawlings D, Park H, Kato R, Witte O, Satterthwaite A
Oncogene
. 1997 Oct;
15(12):1375-83.
PMID: 9333013
Mutations in the nonreceptor tyrosine kinase Btk result in the B cell immunodeficiencies X-linked agammaglobulinemia (XLA) in humans and X-linked immunodeficiency (xid) in mice. Genetic and biochemical evidence implicates Btk...
9.
Wahl M, Fluckiger A, Kato R, Park H, Witte O, Rawlings D
Proc Natl Acad Sci U S A
. 1997 Oct;
94(21):11526-33.
PMID: 9326643
Mutation of Bruton's tyrosine kinase (Btk) impairs B cell maturation and function and results in a clinical phenotype of X-linked agammaglobulinemia. Activation of Btk correlates with an increase in the...
10.
Rawlings D, Scharenberg A, Park H, Wahl M, Lin S, Kato R, et al.
Science
. 1996 Feb;
271(5250):822-5.
PMID: 8629002
Bruton's tyrosine kinase (BTK) is pivotal in B cell activation and development through its participation in the signaling pathways of multiple hematopoietic receptors. The mechanisms controlling BTK activation were studied...