R L Guler

Overview

Explore the profile of R L Guler including associated specialties, affiliations and a list of published articles.

Snapshot

Articles 2

Citations 97

Followers 0

Related Specialties

Oncology

Cell Biology

Co-Authors

S Oesterreich

A V Lee

D Yee

C K Osborne

E M Curran

J L Gooch

W V Welshons

P Zhang

X Sun

Published In

Mol Cell Biol

Cancer Res

Affiliations

Soon will be listed here.

Recent Articles

Re-expression of estrogen receptor alpha in estrogen receptor alpha-negative MCF-7 cells restores both estrogen and insulin-like growth factor-mediated signaling and growth

Oesterreich S, Zhang P, Guler R, Sun X, Curran E, Welshons W, et al.

Cancer Res . 2001 Aug; 61(15):5771-7. PMID: 11479214

Estrogen can increase insulin-like growth factor-I receptor (IGF-IR) and insulin receptor substrate-1 (IRS-1) expression, two key components of IGF-I-mediated signaling. The result is sensitization of breast cancer cells to IGF-I...

Insulin-like growth factor I-induced degradation of insulin receptor substrate 1 is mediated by the 26S proteasome and blocked by phosphatidylinositol 3'-kinase inhibition

Lee A, Gooch J, Oesterreich S, Guler R, Yee D

Mol Cell Biol . 2000 Feb; 20(5):1489-96. PMID: 10669726

Insulin receptor substrate 1 (IRS-1) is a critical adapter protein involved in both insulin and insulin-like growth factor (IGF) signaling. Due to the fact that alteration of IRS-1 levels can...