R L Charnas
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Explore the profile of R L Charnas including associated specialties, affiliations and a list of published articles.
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12
Citations
306
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Recent Articles
1.
Angehrn P, Charnas R, Gubernator K, Gutknecht E, Hubschwerlen C, Kania M, et al.
J Med Chem
. 1998 Oct;
41(21):3961-71.
PMID: 9767633
Bridged monobactams are novel, potent, mechanism-based inhibitors of class C beta-lactamases, designed using X-ray crystal structures of the enzymes. They stabilize the acyl-enzyme intermediate by blocking access of water to...
2.
Oefner C, Darcy A, Daly J, Gubernator K, Charnas R, Heinze I, et al.
Nature
. 1990 Jan;
343(6255):284-8.
PMID: 2300174
Beta-Lactamases (EC 3.5.2.6, 'penicillinases') are a family of enzymes that protect bacteria against the lethal effects of cell-wall synthesis of penicillins, cephalosporins and related antibiotic agents, by hydrolysing the beta-lactam...
3.
Then R, Charnas R, Kocher H, Manneberg M, Rothlisberger U, Stocker J
Rev Infect Dis
. 1988 Jul;
10(4):714-20.
PMID: 3263683
Different types of chromosomally coded beta-lactamases are found in Enterobacter cloacae. E. cloacae M6300 produces beta-lactamase type A, which has an isoelectric point of 8.8, whereas E. cloacae 908 R...
4.
Charnas R, Then R
Rev Infect Dis
. 1988 Jul;
10(4):752-60.
PMID: 3142012
The kinetic interactions of the beta-lactamase from Enterobacter cloacae 908 R with ceftriaxone, cefotaxime, and ceftazidime have been examined in detail. With all of these cephalosporins, there is an initial...
5.
Favaudon V, Charnas R, Goldberg I
Biochemistry
. 1985 Jan;
24(2):250-9.
PMID: 3156631
The anaerobic reaction of poly(deoxyadenylic-deoxythymidylic acid) with neocarzinostatin activated by the carboxyl radical CO2-, an electron donor generated from gamma-ray radiolysis of nitrous oxide saturated formate buffer, has been characterized....
6.
Charnas R, Goldberg I
Biochem Biophys Res Commun
. 1984 Jul;
122(2):642-8.
PMID: 6235811
The oxidative reaction of polydeoxyadenylic-deoxythymidylic acid [poly(dA-dT)] with neocarzinostatin that produces 5'-thymidine aldehyde esterified to the 5'-end of strand breaks proceeds with hydrogen abstraction. The abstracted hydrogen is covalently bound...
7.
Charnas R, Knowles J
Biochemistry
. 1981 May;
20(11):3214-9.
PMID: 7018570
The interaction of the TEM-2 beta-lactamase with 9-deoxyclavulanic acid (3) and with both extensively labeled (2) and specifically labeled (1) clavulanic acid has been studied. The close similarity between 9-doexyclavulanate...
8.
Charnas R, Knowles J
Biochemistry
. 1981 May;
20(10):2732-7.
PMID: 7018565
The interaction of the RTEM beta-lactamase with two derivatives of olivanic acid has been studied. The compound MM22382 (1) behaves simply as a good substrate for the enzyme and is...
9.
Fisher J, Charnas R, Bradley S, Knowles J
Biochemistry
. 1981 May;
20(10):2726-31.
PMID: 7018564
The characteristics of the reaction of a number of mechanism-based inactivators of the RTEM beta-lactamase have suggested that a common mechanistic pathway may be followed by many of these compounds....
10.
Fisher J, Belasco J, Charnas R, Khosla S, Knowles J
Philos Trans R Soc Lond B Biol Sci
. 1980 May;
289(1036):309-19.
PMID: 6109326
The mechanistic pathway followed by the E. coli RTEM beta-lactamase has been studied with a view to clarifying the mode of action of a number of recently discovered inactivators of...