R Kenneth Czambel
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Explore the profile of R Kenneth Czambel including associated specialties, affiliations and a list of published articles.
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Articles
18
Citations
233
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0
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Recent Articles
1.
Bakkenist C, Czambel R, Lin Y, Yates N, Zeng X, Shogan J, et al.
DNA Repair (Amst)
. 2019 Jun;
80:1-7.
PMID: 31176958
Since many anticancer therapies target DNA and DNA damage response pathways, biomarkers of DNA damage endpoints may prove valuable in basic and clinical cancer research. Ataxia telangiectasia-mutated (ATM) kinase is...
2.
Ferry-Galow K, Ji J, Kinders R, Zhang Y, Czambel R, Schmitz J, et al.
Semin Oncol
. 2016 Sep;
43(4):492-500.
PMID: 27663481
Clinical pharmacodynamic assays need to meet higher criteria for sensitivity, precision, robustness, and reproducibility than those expected for research-grade assays because of the long duration of clinical trials and the...
3.
Bakkenist C, Czambel R, Hershberger P, Tawbi H, Beumer J, Schmitz J
Oncoscience
. 2015 Jun;
2(5):542-54.
PMID: 26097887
Pharmacologic inhibition of DNA repair may increase the efficacy of many cytotoxic cancer agents. Inhibitors of DNA repair enzymes including APE1, ATM, ATR, DNA-PK and PARP have been developed and...
4.
Bakkenist C, Czambel R, Clump D, Greenberger J, Beumer J, Schmitz J
Oncotarget
. 2013 Aug;
4(8):1143-8.
PMID: 23900392
Stereotactic body radiation therapy (SBRT) is a radiotherapy modality that delivers highly conformal, ablative doses to a well-defined target. Here, using a semiquantitative multiplexed assay to analyze ATM and H2AX...
5.
Skwara A, Karwoski T, Czambel R, Rubin R, Rhodes M
Behav Brain Res
. 2012 Jun;
234(1):1-10.
PMID: 22705101
In the present study, we determined the effects of environmental enrichment (EE; Kong Toys and Nestlets) on sexually diergic HPA axis responses to single-dose nicotine (NIC), single-dose NIC following continuous...
6.
Gentile N, Andrekanic J, Karwoski T, Czambel R, Rubin R, Rhodes M
Brain Res Bull
. 2011 Mar;
85(3-4):145-52.
PMID: 21396990
Hypothalamic-pituitary-adrenal (HPA) responses to single-dose nicotine (NIC) are sexually diergic: Female rats have higher adrenocorticotropic hormone (ACTH) and corticosterone (CORT) responses than do males. In the present study we determined...
7.
Czambel R, Kharlamov A, Jones S
Nitric Oxide
. 2009 Dec;
22(1):51-7.
PMID: 19948238
No information exists on the differences of eNOS concentration in brain tissue, [eNOS](br), between animals during normal and hypotensive blood pressure and both between and within animals during moderate hypotension....
8.
Pajer K, Tabbah R, Gardner W, Rubin R, Czambel R, Wang Y
Psychoneuroendocrinology
. 2006 Nov;
31(10):1245-56.
PMID: 17126492
There are few data on the biological correlates of female antisocial behavior. This study compared adrenal androgen and gonadal hormone levels in adolescent girls with conduct disorder (CD) to girls...
9.
Rubin R, Rhodes M, Miller T, Jakab R, Czambel R
Life Sci
. 2006 Aug;
79(24):2260-8.
PMID: 16935309
We previously demonstrated greater HPA axis activation in adult men compared to adult women following low-dose administration of the anticholinesterase inhibitor, physostigmine (PHYSO). Because blood sampling was done infrequently following...
10.
Rubin R, Miller T, Rhodes M, Czambel R
Psychiatry Res
. 2006 May;
143(1):43-50.
PMID: 16707164
Increased hypothalamo-pituitary-adrenocortical (HPA) axis activity occurs in 30-50% of patients with major depression. This includes normal-to-increased adrenal cortical hormone (cortisol) secretion in spite of reduced corticotropin (ACTH) stimulation. A possible...