R K Desai
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Explore the profile of R K Desai including associated specialties, affiliations and a list of published articles.
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48
Citations
248
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Recent Articles
11.
Seetharamaiah G, Kurosky A, Desai R, Dallas J, Prabhakar B
Endocrinology
. 1994 Feb;
134(2):549-54.
PMID: 8299554
We produced large quantities of the extracellular domain of the human TSH receptor (ETSHR) using the baculovirus expression system. Insect cells containing the ETSHR protein were sequentially extracted using lysis,...
12.
Wagle N, Dallas J, Seetharamaiah G, Fan J, Desai R, Memar O, et al.
Autoimmunity
. 1994 Jan;
18(2):103-12.
PMID: 7742472
We recently expressed the extracellular domain of the human TSHR (ETSHR) protein using a baculovirus expression system and purified it to homogeneity. The ETSHR specifically binds both TSH and antibodies...
13.
Fan J, Desai R, Seetharamaiah G, Dallas J, Wagle N, Prabhakar B
J Autoimmun
. 1993 Dec;
6(6):799-808.
PMID: 7512341
Graves' disease (GD) is characterized by the presence of autoantibodies to the thyrotropin receptor (TSHr). These antibodies bind to the TSHr and stimulate thyroid cells, thus causing hyperthyroidism. To understand...
14.
Desai R, Dallas J, Gupta M, Seetharamaiah G, Fan J, Tahara K, et al.
J Clin Endocrinol Metab
. 1993 Sep;
77(3):658-63.
PMID: 8103771
To further define the epitopes with which anti-TSH receptor (anti-TSHR) antibodies react and mediate their biological effects, we used antibodies against the extracellular domain of TSHR (ETSHR) protein and nine...
15.
Luo G, Fan J, Seetharamaiah G, Desai R, Dallas J, Wagle N, et al.
J Immunol
. 1993 Jul;
151(2):922-8.
PMID: 8335920
It is well established that autoimmune Graves' disease, which is characterized by hyperthyroidism, is mediated by autoantibodies to the thyrotropin receptor (TSHr). Although what initially triggers this autoantibody response is...
16.
Fan J, Seetharamaiah G, Desai R, Dallas J, Wagle N, Prabhakar B
Autoimmunity
. 1993 Jan;
15(4):285-91.
PMID: 8136456
Graves' disease is characterized by hyperthyroidism leading to enhanced production of thyroid hormones. Hyperthyroidism is primarily mediated by the binding of autoantibodies to the thyrotropin receptor (TSHr). In the past,...
17.
Seetharamaiah G, Desai R, Dallas J, Tahara K, Kohn L, Prabhakar B
Autoimmunity
. 1993 Jan;
14(4):315-20.
PMID: 8102255
A cDNA encoding the extracellular domain of human TSHr (ETSHr) was expressed in large quantities using the baculovirus expression system. Maximum level of protein was produced at 60 hr post-infection...
18.
Thotakura N, Desai R, Szkudlinski M, Weintraub B
Endocrinology
. 1992 Jul;
131(1):82-8.
PMID: 1377127
TSH, a dimeric glycoprotein hormone, has two N-linked complex-type oligosaccharide chains on the alpha-subunit and one on the beta-subunit. The oligosaccharide chains of TSH are important for the expression of...
19.
Lash R, Desai R, Zimmerman C, Flack M, Yoshida T, Wondisford F, et al.
J Endocrinol Invest
. 1992 Apr;
15(4):255-63.
PMID: 1512415
In recent studies, site-directed mutagenesis has been used to alter the tripeptide glycosylation recognition sequences of glycoprotein hormone subunits, thereby affecting their structure and function. However, it is not known...
20.
Desai R, Desberg A
AJR Am J Roentgenol
. 1991 Oct;
157(4):787-8.
PMID: 1892037
No abstract available.