R J Straka
Overview
Explore the profile of R J Straka including associated specialties, affiliations and a list of published articles.
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Articles
27
Citations
215
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0
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Recent Articles
1.
Holzer K, Culhane-Pera K, Straka R, Wen Y, Lo M, Lee K, et al.
J Community Genet
. 2020 Aug;
12(1):53-65.
PMID: 32761465
Pharmacogenetic research has historically lacked racial and ethnic diversity, limiting the application of findings to minority populations. Recent studies, including the Hmong, have gauged communities' interest in participating in genomic...
2.
Trottier J, Perreault M, Rudkowska I, Levy C, Dallaire-Theroux A, Verreault M, et al.
Clin Pharmacol Ther
. 2013 Jun;
94(4):533-43.
PMID: 23756370
Glucuronidation, catalyzed by uridine 5'-diphospho-glucuronosyltransferase (UGT) enzymes, detoxifies cholestatic bile acids (BAs). We aimed to (i) characterize the circulating BA-glucuronide (BA-G) pool composition in humans, (ii) determine how sex and...
3.
Aslibekyan S, An P, Frazier-Wood A, Kabagambe E, Irvin M, Straka R, et al.
Nutr Metab Cardiovasc Dis
. 2012 Nov;
23(10):987-94.
PMID: 23149075
Background And Aims: Adiponectin is an adipose-secreted protein that has been linked to changes in insulin sensitivity, high-density lipoprotein cholesterol levels, and inflammatory patterns. Although fenofibrate therapy can raise adiponectin...
4.
Frazier-Wood A, Ordovas J, Straka R, Hixson J, Borecki I, Tiwari H, et al.
Pharmacogenomics J
. 2012 May;
13(4):312-7.
PMID: 22547144
As a peroxisome proliferator-activated receptor alpha (PPARα) agonist, fenofibrate favorably modulates dyslipidemia and inflammation markers, which are associated with cardiovascular risk. To determine whether variation in the PPARα receptor gene...
5.
Trottier J, Caron P, Straka R, Barbier O
Clin Pharmacol Ther
. 2011 Jul;
90(2):279-86.
PMID: 21716269
Fenofibrate belongs to the group of hypolipidemic fibrates that act as activators of the peroxisome proliferator-activated receptor-α (PPARα), which is a regulator of bile acid synthesis, metabolism, and transport. The...
6.
Junyent M, Parnell L, Lai C, Arnett D, Tsai M, Kabagambe E, et al.
Nutr Metab Cardiovasc Dis
. 2009 Oct;
20(10):698-705.
PMID: 19819120
Background And Aims: The disintegrin and metalloproteinase ADAM17, also known as tumor necrosis factor alpha converting enzyme, is expressed in adipocytes. Importantly, elevated levels of ADAM17 expression have been linked...
7.
Junyent M, Lee Y, Smith C, Arnett D, Tsai M, Kabagambe E, et al.
Nutr Metab Cardiovasc Dis
. 2009 Apr;
20(1):34-40.
PMID: 19364639
Background And Aims: Several genes have been shown to individually affect plasma lipoprotein metabolism in humans. Studies on gene-gene interactions could offer more insight into how genes affect lipid metabolism...
8.
Straka R, Taheri R, Cooper S, Tan A, Smith A
Pharmacotherapy
. 2001 Jul;
21(7):818-27.
PMID: 11444578
To determine the extent of achievement of goal low-density lipoprotein cholesterol (LDL) as defined by National Cholesterol Education Program-Adult Treatment Panel II (NCEP-ATP 11) and American Diabetes Association (ADA) 2000...
9.
Matzke G, Frye R, Early J, Straka R, Carson S
Pharmacotherapy
. 2000 Mar;
20(2):182-90.
PMID: 10678296
Study Objective: To evaluate the metabolism of antipyrine, a general metabolic probe, caffeine, a probe for cytochrome P450 (CYP) 1A2 and N-acetyltransferase activity, and dextromethorphan, a specific probe for CYP2D6...
10.
Straka R, SWANSON A, Parra D
Am Fam Physician
. 1998 Apr;
57(7):1551-60.
PMID: 9556644
Recent studies have shown an association between the use of calcium channel antagonists for the treatment of hypertension and an increased risk of myocardial infarction, gastrointestinal hemorrhage and cancer. The...