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R J McCrimmon

Explore the profile of R J McCrimmon including associated specialties, affiliations and a list of published articles. Areas
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Articles 25
Citations 400
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Recent Articles
1.
de Galan B, McCrimmon R, Ibberson M, Heller S, Choudhary P, Pouwer F, et al.
Diabet Med . 2020 Jan; 37(6):1066-1073. PMID: 31970814
Background: Hypoglycaemia is the most frequent complication of treatment with insulin or insulin secretagogues in people with diabetes. Severe hypoglycaemia, i.e. an event requiring external help because of cognitive dysfunction,...
2.
Campbell R, Colhoun H, Kennon B, McCrimmon R, Sattar N, McKnight J, et al.
Diabet Med . 2020 Jan; 37(12):2081-2088. PMID: 31967666
Aims: To describe the association between socio-economic status and mortality in a nation-wide cohort of people with type 1 diabetes in Scotland and to compare patterns over time and with...
3.
McGurnaghan S, Blackbourn L, Mocevic E, Haagen Panton U, McCrimmon R, Sattar N, et al.
Diabet Med . 2018 Sep; 36(6):718-725. PMID: 30246473
Aims: To describe the prevalence of major cardiovascular disease (CVD) and risk factor control in a contemporary population with Type 2 diabetes. Methods: We used data from the national registry...
4.
Read S, McAllister D, Colhoun H, Farran B, Fischbacher C, Kerssens J, et al.
Diabet Med . 2017 Oct; 35(1):99-106. PMID: 29044687
Aim: To describe trends in first ischaemic stroke incidence and case fatality in adults with and without a diagnosis of Type 2 diabetes prior to their ischaemic stroke event in...
5.
McCrimmon R
Diabet Med . 2016 Oct; 34(2):148-155. PMID: 27770582
Despite the introduction of newer technologies and improved insulin formulations, recurrent hypoglycaemia continues to affect the lives of many people with Type 1 and Type 2 diabetes. Developing strategies or...
6.
George P, McCrimmon R
Diabet Med . 2015 Dec; 33(9):1283-90. PMID: 26642301
Aims: To test the hypothesis that dipeptidyl peptidase-4 inhibition in C-peptide negative Type 1 diabetes would reduce glucose variability and exposure to hypoglycaemia and therefore may indirectly enhance counter-regulatory responses...
7.
George P, McCrimmon R
Diabet Med . 2012 Jul; 30(2):179-88. PMID: 22804102
Despite improvements in the pharmacodynamics of injectable insulin and better insulin delivery systems, glucose control remains suboptimal in the majority of individuals with Type 1 diabetes. Profound defects in the...
8.
Beall C, Hamilton D, Gallagher J, Logie L, Wright K, Soutar M, et al.
Diabetologia . 2012 Jul; 55(9):2432-44. PMID: 22760787
Aims/hypothesis: Hypothalamic glucose-excited (GE) neurons contribute to whole-body glucose homeostasis and participate in the detection of hypoglycaemia. This system appears defective in type 1 diabetes, in which hypoglycaemia commonly occurs....
9.
Fan X, Ding Y, Brown S, Zhou L, Shaw M, Vella M, et al.
Am J Physiol Regul Integr Comp Physiol . 2009 Apr; 296(6):R1702-8. PMID: 19357294
In nondiabetic rodents, AMP-activated protein kinase (AMPK) plays a role in the glucose-sensing mechanism used by the ventromedial hypothalamus (VMH), a key brain region involved in the detection of hypoglycemia....
10.
McCrimmon R, Jacob R, Fan X, McNay E, Sherwin R
Diabetologia . 2003 Nov; 46(12):1658-61. PMID: 14600813
Aims/hypothesis: Our aim was to determine whether the divergent effects of chronic exposure to hyperglycaemia or hypoglycaemia on the glycaemic threshold for auditory brainstem dysfunction are reflected in the extra-cellular...