R J M Franklin
Overview
Explore the profile of R J M Franklin including associated specialties, affiliations and a list of published articles.
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20
Citations
1193
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Recent Articles
1.
Hill M, Cunniffe N, Franklin R
Curr Opin Pharmacol
. 2022 Aug;
66:102269.
PMID: 35926475
Remyelination is the regenerative process by which lost myelin sheaths are restored to demyelinated axons. It is a key target in the treatment of chronic demyelinating disorders such as multiple...
2.
Conejos-Sanchez I, Gallon E, Nino-Pariente A, Smith J, De la Fuente A, Di Canio L, et al.
Nanoscale
. 2019 Dec;
12(11):6285-6299.
PMID: 31840717
Gene silencing therapies have successfully suppressed the translation of target proteins, a strategy that holds great promise for the treatment of central nervous system (CNS) disorders. Advances in the current...
3.
Crawford A, Stockley J, Tripathi R, Richardson W, Franklin R
Exp Neurol
. 2014 May;
260:50-5.
PMID: 24800913
Oligodendrocyte progenitors (OPs) are a major proliferating cell population within the adult CNS. In response to myelin loss or increasing demand, OPs have the capacity to differentiate into mature, myelinating...
4.
Crawford A, Chambers C, Franklin R
J Comp Pathol
. 2013 Jul;
149(2-3):242-54.
PMID: 23831056
The myelin sheath, generated by oligodendrocytes in the central nervous system (CNS), is crucial to neuronal function, enabling rapid propagation of nerve impulses and providing trophic support to the axon....
5.
Stacpoole S, Bilican B, Webber D, Luzhynskaya A, He X, Compston A, et al.
Nat Protoc
. 2011 Jul;
6(8):1229-40.
PMID: 21799491
This protocol has been designed to generate neural precursor cells (NPCs) from human embryonic stem cells (hESCs) using a physiological oxygen (O(2)) level of 3% (previously termed hypoxia) and chemically...
6.
Stacpoole S, Bilican B, Webber D, Luzhynskaya A, He X, Compston A, et al.
Cell Death Differ
. 2011 Jan;
18(6):1016-23.
PMID: 21274009
In vitro stem cell systems traditionally employ oxygen levels that are far removed from the in vivo situation. This study investigates whether an ambient environment containing a physiological oxygen level...
7.
Anderson J, Hampton D, Patani R, Pryce G, Crowther R, Reynolds R, et al.
Brain
. 2008 Jun;
131(Pt 7):1736-48.
PMID: 18567922
The pathological correlate of clinical disability and progression in multiple sclerosis is neuronal and axonal loss; however, the underlying mechanisms are unknown. Abnormal phosphorylation of tau is a common feature...
8.
Neumann H, Kotter M, Franklin R
Brain
. 2008 Jun;
132(Pt 2):288-95.
PMID: 18567623
Microglia are cells of myeloid origin that populate the CNS during early development and form the brain's innate immune cell type. They perform homoeostatic activity in the normal CNS, a...
9.
Blakemore W, Franklin R
Curr Top Microbiol Immunol
. 2008 Jan;
318:193-212.
PMID: 18219819
Remyelination is the regenerative process by which demyelinated axons are reinvested with new myelin sheaths. It is associated with functional recovery and maintenance of axonal health. It occurs as a...
10.
Palmer A, Jeffery N, Franklin R
Vet Pathol
. 2007 Nov;
44(6):949-51.
PMID: 18039912
A Siamese kitten presented with mild gait dysfunction associated with periodic circling. Pathologic investigation revealed unilateral (right-sided) absence of the corticospinal (pyramidal) tract throughout its normal course. Although an infectious...