R J Knox
Overview
Explore the profile of R J Knox including associated specialties, affiliations and a list of published articles.
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Articles
76
Citations
851
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0
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Recent Articles
1.
Knox R, Burns N, Van Alstine J, Harris J, Seaman G
Anal Chem
. 2011 Jun;
70(11):2268-79.
PMID: 21644639
Electrophoretic analysis of colloidal particles is adversely affected by a host of surface phenomena, including electroosmosis, phase wall wetting, and sample or air bubble adsorption. Neutral, hydrophilic polymer coatings control...
2.
Jamieson D, Tung A, Knox R, Boddy A
Br J Cancer
. 2006 Oct;
95(9):1229-33.
PMID: 17031400
NRH:Quinone Oxidoreductase 2 (NQO2) has been described as having no enzymatic activity with nicotinamide adenine dinucleotide (NADH) or NADPH as electron donating cosubstrates. Mitomycin C (MMC) is both a substrate...
3.
Bagshawe K, Burke P, Knox R, Melton R, Sharma S
Expert Opin Investig Drugs
. 2005 Jul;
8(2):161-72.
PMID: 15992070
Two methods of using tumour located enzymes have been described. These are antibody directed enzyme prodrug therapy (ADEPT) and macromolecule directed enzyme prodrug therapy (MDEPT), where the tumour located enzyme...
4.
Skelly J, Knox R, Jenkins T
Mini Rev Med Chem
. 2002 Oct;
1(3):293-306.
PMID: 12369976
NQO1 (DT-diaphorase) and its truncated isoenzyme, the metalloenzyme NQO2, can reduce quinone substrates by two-electron transfer. While NQO1 is a known detoxification enzyme, the function of NQO2 is less well...
5.
Plumb J, Bilsland A, Kakani R, Zhao J, Glasspool R, Knox R, et al.
Oncogene
. 2001 Dec;
20(53):7797-803.
PMID: 11753658
Telomerase activation is considered to be a critical step in cancer progression due to its role in cellular immortalization. The prevalence of telomerase expression in human cancers makes it an...
6.
7.
Bailey S, Lewis A, Patterson L, FISHER G, Knox R, Workman P
Biochem Pharmacol
. 2001 Jul;
62(4):461-8.
PMID: 11448456
Evidence suggests that DT-diaphorase is involved in the activation and mechanism of cytotoxicity of the investigational indoloquinone anticancer drug EO9 under aerobic conditions. Data also implicate a role for other...
8.
Knox R, Gigantelli J, Arthurs B
Ophthalmic Plast Reconstr Surg
. 2001 Apr;
17(2):137-9.
PMID: 11281589
Purpose: To report an unusual clinical presentation for carcinoid tumor metastatic to the orbit. Methods: Two adult patients with metastatic carcinoid tumor and unilateral orbital masses are described. Results: Both...
9.
Seaman G, Knox R
Electrophoresis
. 2001 Mar;
22(3):373-85.
PMID: 11258742
Process control is an increasingly important issue as life science companies world-wide strive for recognition of their manufacturing and product development quality measures according to International Standards Organization (ISO) or...
10.
Knox R, Jenkins T, Hobbs S, Chen S, Melton R, Burke P
Cancer Res
. 2000 Aug;
60(15):4179-86.
PMID: 10945627
A novel prodrug activation system, endogenous in human tumor cells, is described. A latent enzyme-prodrug system is switched on by a simple synthetic, small molecule co-substrate. This ternary system is...