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R Isaacson

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Articles 17
Citations 160
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Recent Articles
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Seifan A, Isaacson R
J Prev Alzheimers Dis . 2017 May; 2(4):254-266. PMID: 28529933
In July 2013, Weill Cornell Medical College founded the first Alzheimer's Prevention Clinic (APC) in the United States, providing direct clinical care to family members of patients with Alzheimer's disease...
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Chiang G, Mao X, Kang G, Chang E, Pandya S, Vallabhajosula S, et al.
AJNR Am J Neuroradiol . 2017 Mar; 38(6):1130-1137. PMID: 28341718
Background And Purpose: Oxidative stress has been implicated as an important pathologic mechanism in the development of Alzheimer disease. The purpose of this study was to assess whether glutathione levels,...
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Paddock M, Flores M, Isaacson R, Shepherd J, Okamura M
Appl Magn Reson . 2010 Feb; 37(1-4):39. PMID: 20157643
In photosynthetic bacteria, light-induced electron transfer takes place in a protein called the reaction center (RC) leading to the reduction of a bound ubiquinone molecule, Q(B), coupled with proton binding...
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Paulin-Curlee G, Sreevatsan S, Singer R, Isaacson R, Reneau J, Bey R, et al.
J Dairy Sci . 2008 Jan; 91(2):554-63. PMID: 18218741
Despite advances in controlling mastitis (inflammation of the mammary gland), udder infections caused by Klebsiella pneumoniae continue to affect dairy cattle. Mastitis caused by K. pneumoniae responds poorly to antibiotic...
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Paulin-Curlee G, Singer R, Sreevatsan S, Isaacson R, Reneau J, Foster D, et al.
J Dairy Sci . 2007 Jul; 90(8):3681-9. PMID: 17638979
The objectives of this study were to determine the level of genetic diversity of Klebsiella pneumoniae isolated from clinical mastitis cases and to define genotypes most commonly associated with the...
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Paddock M, Flores M, Isaacson R, Chang C, Abresch E, Okamura M
Biochemistry . 2007 Jun; 46(28):8234-43. PMID: 17590017
Proton ENDOR spectroscopy was used to monitor local conformational changes in bacterial reaction centers (RC) associated with the electron-transfer reaction DQB --> D+*QB-* using mutant RCs capable of photoreducing QB...
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Paddock M, Flores M, Isaacson R, Chang C, Abresch E, Selvaduray P, et al.
Biochemistry . 2006 Nov; 45(47):14032-42. PMID: 17115698
The reaction center (RC) from Rhodobacter sphaeroides captures light energy by electron transfer between quinones QA and QB, involving a conformational gating step. In this work, conformational states of D+*QB-*...
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Flores M, Isaacson R, Abresch E, Calvo R, Lubitz W, Feher G
Biophys J . 2006 Oct; 92(2):671-82. PMID: 17071655
The geometry of the hydrogen bonds to the two carbonyl oxygens of the semiquinone Q(A)(. -) in the reaction center (RC) from the photosynthetic purple bacterium Rhodobacter sphaeroides R-26 were...
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Flores M, Isaacson R, Abresch E, Calvo R, Lubitz W, Feher G
Biophys J . 2006 Feb; 90(9):3356-62. PMID: 16473904
Hydrogen bonds are important in determining the structure and function of biomolecules. Of particular interest are hydrogen bonds to quinones, which play an important role in the bioenergetics of respiration...