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R HILF

Explore the profile of R HILF including associated specialties, affiliations and a list of published articles. Areas
Snapshot
Articles 212
Citations 1627
Followers 0
Related Specialties
Oncology
Biochemistry
Biology
Top 10 Co-Authors
S L Gibson
R A Bambara
C M Klinge
I Michel
A Borman
C Bell
R S Murant
E D SAVLOV
S Zain
T H Foster
Published In
Cancer Res
Photochem Photobiol
Endocrinology
Biochim Biophys Acta
Cancer
Affiliations
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Recent Articles
1.
Fusion estrogen receptor proteins: toward the development of receptor-based agonists and antagonists
Muyan M, Yi P, Sathya G, Willmert L, Driscoll M, HILF R, et al.
Mol Cell Endocrinol . 2001 Aug; 182(2):249-63. PMID: 11514059
Estrogen-induced signaling mediated by estrogen receptors (ERs) is also affected by aberrant ERs that act as constitutively active or dominant negative modulators. Variant ERs can contribute to carcinogenesis and to...
2.
Is delta-aminolevulinic acid dehydratase rate limiting in heme biosynthesis following exposure of cells to delta-aminolevulinic acid?
Gibson S, Havens J, Metz L, HILF R
Photochem Photobiol . 2001 Apr; 73(3):312-7. PMID: 11281029
Understanding the regulation and control of heme/porphyrin biosynthesis is critical for the optimization of the delta-aminolevulinic-acid (ALA)-mediated photodynamic therapy of cancer, in which endogenously produced protoporphyrin IX (PPIX) is the...
3.
A selenopyrylium photosensitizer for photodynamic therapy related in structure to the antitumor agent AA1 with potent in vivo activity and no long-term skin photosensitization
Leonard K, Hall J, Nelen M, Davies S, Gollnick S, Camacho S, et al.
J Med Chem . 2000 Nov; 43(23):4488-98. PMID: 11087573
Cationic chalcogenopyrylium dyes 5 were synthesized in six steps from p-aminophenylacetylene (9), have absorption maxima in methanol of 623, 654, and 680 nm for thio-, seleno-, and telluropyrylium dyes, respectively,...
4.
Water-soluble, core-modified porphyrins as novel, longer-wavelength-absorbing sensitizers for photodynamic therapy
Stilts C, Nelen M, Hilmey D, Davies S, Gollnick S, Oseroff A, et al.
J Med Chem . 2000 Jul; 43(12):2403-10. PMID: 10882367
Water-soluble, core-modified 5,10,15, 20-tetrakis(4-sulfonatophenyl)-21,23-dithiaporphyrin (1) and 5,10,15, 20-tetrakis(4-sulfonatophenyl)-21,23-diselenaporphyrin (2) were prepared as the tetrasodium salts by the sulfonation of 5,10,15, 20-tetraphenyl-21,23-dithiaporphyrin (3) and -21, 23-diselenaporphyrin (4), respectively, with sulfuric acid....
5.
Effect of estrogenic perturbations on delta-aminolevulinic acid-induced porphobilinogen deaminase and protoporphyrin IX levels in rat Harderian glands, liver, and R3230AC tumors
Gibson S, ANDERSON L, Havens J, HILF R
Biochem Pharmacol . 1999 Nov; 58(11):1821-9. PMID: 10571258
The Harderian gland in rodents highly expresses enzymes of the heme biosynthetic pathway that are responsible for porphyrin production. Interestingly, many of the steps in Harderian gland heme biosynthesis, including...
6.
Relationship of delta-aminolevulinic acid-induced protoporphyrin IX levels to mitochondrial content in neoplastic cells in vitro
Gibson S, Nguyen M, Havens J, Barbarin A, HILF R
Biochem Biophys Res Commun . 1999 Nov; 265(2):315-21. PMID: 10558864
Protoporphyrin IX, induced by the exogenous addition of delta-aminolevulinic acid, reaches different levels in different tumor cells. Because many of the steps in heme biosynthesis, of which protoporphyrin IX is...
7.
Synthesis and evaluation of chalcogenopyrylium dyes as potential sensitizers for the photodynamic therapy of cancer
Leonard K, Nelen M, Simard T, Davies S, Gollnick S, Oseroff A, et al.
J Med Chem . 1999 Oct; 42(19):3953-64. PMID: 10508443
A series of thiopyrylium (2), selenopyrylium (3), and telluropyrylium dyes (4) was prepared via the addition of Grignard reagents to either 2, 6-di(4-dimethylamino)phenylchalcogenopyran-4-ones (5a) or 2-[4-(dimethylamino)phenyl]-6-phenylchalcogenopyran-4-ones (5b) followed by elimination...
8.
2,4,6-triarylchalcogenopyrylium dyes related in structure to the antitumor agent AA1 as in vitro sensitizers for the photodynamic therapy of cancer
Leonard K, Nelen M, ANDERSON L, Gibson S, HILF R, Detty M
J Med Chem . 1999 Oct; 42(19):3942-52. PMID: 10508442
Cationic chalcogenopyrylium dyes 2-4 were synthesized in six steps from 4-(dimethylamino)phenylethyne (7), have absorption maxima in methanol of 594, 631, and 672 nm, respectively, and generate singlet oxygen with quantum...
9.
Effect of delta-aminolevulinic acid on protoporphyrin IX accumulation in tumor cells transfected with plasmids containing porphobilinogen deaminase DNA
HILF R, Havens J, Gibson S
Photochem Photobiol . 1999 Sep; 70(3):334-40. PMID: 10483361
Recently, we reported that the delta-aminolevulinic acid (delta-ALA)-induced increase in porphobilinogen deaminase (PBGD) activity was closely correlated with an increase in the accumulation of protoporphyrin IX (PPIX), resulting in augmented...
10.
An explanation for observed estrogen receptor binding to single-stranded estrogen-responsive element DNA
Driscoll M, Sathya G, Saidi L, DeMott M, HILF R, Bambara R
Mol Endocrinol . 1999 Jun; 13(6):958-68. PMID: 10379894
Estrogen-inducible genes contain an enhancer called the estrogen response element (ERE), a double-stranded inverted repeat. The estrogen receptor (ER) is generally thought to bind to the double-stranded ERE. However, some...