R H. Buckingham
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Explore the profile of R H. Buckingham including associated specialties, affiliations and a list of published articles.
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64
Citations
1097
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Recent Articles
1.
Vestergaard B, Van L, Andersen G, Nyborg J, Buckingham R, Kjeldgaard M
Mol Cell
. 2002 Jan;
8(6):1375-82.
PMID: 11779511
Bacterial release factor RF2 promotes termination of protein synthesis, specifically recognizing stop codons UAA or UGA. The crystal structure of Escherichia coli RF2 has been determined to a resolution of...
2.
Zavialov A, Buckingham R, Ehrenberg M
Cell
. 2001 Oct;
107(1):115-24.
PMID: 11595190
The mechanism by which peptide release factor RF3 recycles RF1 and RF2 has been clarified and incorporated in a complete scheme for translation termination. Free RF3 is in vivo stably...
3.
de Zamaroczy M, Mora L, Lecuyer A, Geli V, Buckingham R
Mol Cell
. 2001 Aug;
8(1):159-68.
PMID: 11511369
Colicin D is known to kill target cells by cleaving tRNA(Arg). A colicin D-resistant mutant was selected that was altered in the inner membrane leader peptidase, LepB. The substituted residue...
4.
Menez J, Buckingham R
Nucleic Acids Res
. 2000 Nov;
28(23):4725-32.
PMID: 11095683
High-level expression of non-functional model proteins, derived from elongation factor EF-Tu by the deletion of an essential domain, greatly inhibits the growth of Escherichia coli partly deficient in peptidyl-tRNA hydrolase....
5.
Kisselev L, Buckingham R
Trends Biochem Sci
. 2000 Nov;
25(11):561-6.
PMID: 11084369
Translational termination has been a largely ignored aspect of protein synthesis for many years. However, the recent identification of new release-factor genes, the mapping of release-factor functional sites and in...
6.
Dincbas V, Buckingham R, Ehrenberg M
EMBO J
. 2000 Jun;
19(11):2701-9.
PMID: 10835367
The expression of very short open reading frames in Escherichia coli can lead to the inhibition of translation and an arrest in cell growth. Inhibition occurs because peptidyl-tRNA hydrolase fails...
7.
Freistroffer D, Kwiatkowski M, Buckingham R, Ehrenberg M
Proc Natl Acad Sci U S A
. 2000 Feb;
97(5):2046-51.
PMID: 10681447
The precision with which individual termination codons in mRNA are recognized by protein release factors (RFs) has been measured and compared with the decoding of sense codons by tRNA. An...
8.
Dincbas V, Buckingham R, Karimi R, Ehrenberg M
J Mol Biol
. 1999 Aug;
291(4):745-59.
PMID: 10452886
Mutants of Escherichia coli partially deficient in peptidyl-tRNA hydrolase are killed by the expression of certain very short open reading frames (mini-genes), encoded by the wild-type bar regions of phage...
9.
Karimi R, Pavlov M, Buckingham R, Ehrenberg M
Mol Cell
. 1999 Jun;
3(5):601-9.
PMID: 10360176
The pathway of bacterial ribosome recycling following translation termination has remained obscure. Here, we elucidate two essential steps and describe the roles played by the three translation factors EF-G, RRF,...
10.
Pavlov M, Freistroffer D, Dincbas V, MacDougall J, Buckingham R, Ehrenberg M
J Mol Biol
. 1998 Nov;
284(3):579-90.
PMID: 9826500
An in vitro assay in which terminating Escherichia coli ribosomes with different stop signals in the A-site compete for a limited amount of a release factor (RF1 or RF2) has...