R El-Khoueiry
Overview
Explore the profile of R El-Khoueiry including associated specialties, affiliations and a list of published articles.
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10
Citations
77
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Recent Articles
1.
Matsusaka S, Cao S, Hanna D, Sunakawa Y, Ueno M, Mizunuma N, et al.
Pharmacogenomics J
. 2016 Aug;
17(6):543-550.
PMID: 27503580
We analyzed associations between CXCR4/CXCL12 single-nucleotide polymorphisms and outcomes in metastatic colorectal cancer (mCRC) patients who underwent first-line bevacizumab-based chemotherapy. A total of 874 patients were included in this study:...
2.
Stremitzer S, Berghoff A, Volz N, Zhang W, Yang D, Stintzing S, et al.
Pharmacogenomics J
. 2015 Dec;
17(1):29-35.
PMID: 26689941
Colorectal brain metastases (BM) are rare (1-2%) and a late-stage disease manifestation. Molecular mechanisms for BM development are not well understood. We tested whether variants within genes involved in overcoming...
3.
Stremitzer S, Zhang W, Yang D, Ning Y, Stintzing S, Sunakawa Y, et al.
Ann Oncol
. 2015 May;
26(8):1728-33.
PMID: 25957329
Background: Tumor dormancy has been described as a state of hibernation. Dormancy can be switched to proliferation by different pathways, which may play a critical role in tumor recurrence. In...
4.
Stremitzer S, Sunakawa Y, Zhang W, Yang D, Ning Y, Stintzing S, et al.
Pharmacogenomics J
. 2015 Mar;
15(6):521-9.
PMID: 25752522
In patients with colorectal liver metastases (CLM), liver resection offers the possibility of cure and long-term survival. The liver is a highly immunogenic organ harboring ~80% of the body's tissue...
5.
Bohanes P, Yang D, Loupakis F, LaBonte M, Gerger A, Ning Y, et al.
Pharmacogenomics J
. 2014 Dec;
15(3):226-34.
PMID: 25487679
Integrins (ITGs) are key elements in cancer biology, regulating tumor growth, angiogenesis and lymphangiogenesis through interactions of the tumor cells with the microenvironment. Moving from the hypothesis that ITGs could...
6.
Sunakawa Y, Stremitzer S, Cao S, Zhang W, Yang D, Wakatsuki T, et al.
Ann Oncol
. 2014 Nov;
26(2):332-9.
PMID: 25411415
Background: Nuclear factor-kappaB (NF-κB) and CCL2/CCR2 chemokine axis play a central role in tumor progression such as stimulation of angiogenesis, acceleration of tumor invasion and migration, and suppression of innate...
7.
Benhaim L, Zhang W, Wakatsuki T, Yang D, Gerger A, Bohanes P, et al.
Pharmacogenomics J
. 2014 Oct;
15(3):235-40.
PMID: 25287073
In patients with breast cancer (BC), deregulation of estrogen receptor (ERα) activity may account for most resistance to endocrine therapies. Our previous study used a whole-human kinome siRNA screen to...
8.
Loupakis F, Antoniotti C, Cremolini C, Zhang W, Yang D, Wakatsuki T, et al.
Pharmacogenomics J
. 2014 Feb;
14(4):322-7.
PMID: 24513691
The number of CA tandem repeats (CA)n in a highly polymorphic region of EGFR (epidermal growth factor receptor) intron 1 may affect gene transcription; the potential impact of allelic variants...
9.
Benhaim L, Gerger A, Bohanes P, Paez D, Wakatsuki T, Yang D, et al.
Pharmacogenomics J
. 2013 Jun;
14(2):135-41.
PMID: 23752739
This study was designed to analyze the gender-related association between SCN1A polymorphisms (voltage-gated sodium channels; α-subunit) and time-to-recurrence (TTR) in patients with colorectal cancer (CRC) treated with 5-fluoruracil (5-FU)-based adjuvant...
10.
LaBonte M, Wilson P, Yang D, Zhang W, Ladner R, Ning Y, et al.
Ann Oncol
. 2011 Oct;
23(6):1455-64.
PMID: 21989330
Background: Lapatinib plus capecitabine emerged as an efficacious therapy in metastatic breast cancer (mBC). We aimed to identify germline single-nucleotide polymorphisms (SNPs) in genes involved in capecitabine catabolism and human...