R E Chapin
Overview
Explore the profile of R E Chapin including associated specialties, affiliations and a list of published articles.
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Articles
115
Citations
1011
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Recent Articles
1.
Reda A, Hou M, Winton T, Chapin R, Soder O, Stukenborg J
Mol Hum Reprod
. 2016 Jul;
22(9):601-12.
PMID: 27430551
Study Question: Do the organ culture conditions, previously defined for in vitro murine male germ cell differentiation, also result in differentiation of rat spermatogonia into post-meiotic germ cells exhibiting specific...
2.
3.
Chapin R, Phelps J
Toxicol In Vitro
. 2010 Aug;
4(4-5):543-59.
PMID: 20702229
No abstract available.
4.
Ku W, Chapin R
Toxicol In Vitro
. 2010 Aug;
8(6):1191-202.
PMID: 20693088
Cultures of isolated testicular cells are widely used for evaluating mechanisms of action of direct-acting testicular toxicants. However, for testicular cells, the expression of toxicity in vitro is frequently different...
5.
Marty M, Allen B, Chapin R, Cooper R, Daston G, Flaws J, et al.
Birth Defects Res B Dev Reprod Toxicol
. 2009 Nov;
86(6):470-89.
PMID: 19918951
Background: The U.S. EPA revised the Reproduction and Fertility Effects Test Guideline (OPPTS 870.3800/OECD 416) in 1998, adding numerous endpoints in an effort to incorporate new methodologies, improve the sensitivity...
6.
Cappon G, Fleeman T, Chapin R, Hurtt M
Birth Defects Res B Dev Reprod Toxicol
. 2005 Oct;
74(5):424-30.
PMID: 16249998
Background: Appropriate maternal nutrition and body weight gain during pregnancy is well established as a major factor in healthy prenatal development in humans. Given the role of nutrition and body...
7.
Terry K, Chatman L, Foley G, Kadyszewski E, Fleeman T, Hurtt M, et al.
Birth Defects Res B Dev Reprod Toxicol
. 2005 Oct;
74(5):431-41.
PMID: 16249996
Background: Feed restriction with its resultant body weight loss impacts the rodent estrous cycle; however, the manifestation of these changes in a regulatory study design has not been documented. This...
8.
Fleeman T, Cappon G, Chapin R, Hurtt M
Birth Defects Res B Dev Reprod Toxicol
. 2005 Sep;
74(5):442-9.
PMID: 16193501
Background: Given the role of nutrition and body weight gain in normal development, pharmaceuticals intended to reduce appetite and promote weight loss will generate safety data that may be challenging...
9.
Chapin R
Hum Exp Toxicol
. 2002 Dec;
21(9-10):521-3.
PMID: 12458910
The benefits and costs are discussed for the possibility of using pups generated in breeding studies for additional assessments, such as evaluating immunotoxicity. Such an approach is logistically challenging, but...
10.
Odum J, Lefevre P, Tinwell H, Van Miller J, Joiner R, Chapin R, et al.
Toxicol Sci
. 2002 Jun;
68(1):147-63.
PMID: 12075118
The objective of the study was to determine which period of exposure produces the most marked effects on the reproductive capacity and sexual development of the rat, with particular emphasis...