R D Vale
Overview
Explore the profile of R D Vale including associated specialties, affiliations and a list of published articles.
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Articles
104
Citations
7440
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Recent Articles
1.
Shepard K, Gerber A, Jambhekar A, Takizawa P, Brown P, Herschlag D, et al.
Proc Natl Acad Sci U S A
. 2003 Sep;
100(20):11429-34.
PMID: 13679573
Cytoplasmic mRNA localization provides a means of generating cell asymmetry and segregating protein activity. Previous studies have identified two mRNAs that localize to the bud tips of the yeast Saccharomyces...
2.
Dell K, Turck C, Vale R
Traffic
. 2001 Feb;
1(1):38-44.
PMID: 11208058
Cytoplasmic dynein, a large minus-end-directed microtubule motor, performs multiple functions during the cell cycle. In interphase, dynein moves membrane organelles, while in mitosis it moves chromosomes and helps to form...
3.
Vale R, Milligan R
Science
. 2001 Feb;
288(5463):88-95.
PMID: 10753125
The microtubule-based kinesin motors and actin-based myosin motors generate motions associated with intracellular trafficking, cell division, and muscle contraction. Early studies suggested that these molecular motors work by very different...
4.
Klopfenstein D, Vale R, Rogers S
Cell
. 2000 Dec;
103(4):537-40.
PMID: 11106727
No abstract available.
5.
Wilhelm J, Vale R, Hegde R
Proc Natl Acad Sci U S A
. 2000 Nov;
97(24):13132-7.
PMID: 11087864
Vg1, a member of the transforming growth factor-beta family involved in mesoderm induction, is translated subsequent to the localization of its mRNA to the vegetal pole of Xenopus oocytes. Whereas...
6.
Thorn K, Ubersax J, Vale R
J Cell Biol
. 2000 Nov;
151(5):1093-100.
PMID: 11086010
Conventional kinesin is a highly processive molecular motor that takes several hundred steps per encounter with a microtubule. Processive motility is believed to result from the coordinated, hand-over-hand motion of...
7.
Tomishige M, Vale R
J Cell Biol
. 2000 Nov;
151(5):1081-92.
PMID: 11086009
Conventional kinesin, a dimeric molecular motor, uses ATP-dependent conformational changes to move unidirectionally along a row of tubulin subunits on a microtubule. Two models have been advanced for the major...
8.
Prahlad V, Helfand B, Langford G, Vale R, Goldman R
J Cell Sci
. 2000 Nov;
113 ( Pt 22):3939-46.
PMID: 11058081
Using squid axoplasm as a model system, we have visualized the fast transport of non-filamentous neurofilament protein particles along axonal microtubules. This transport occurs at speeds of 0.5-1.0 microm/second and...
9.
Takizawa P, DeRisi J, Wilhelm J, Vale R
Science
. 2000 Oct;
290(5490):341-4.
PMID: 11030653
Asymmetric localization of proteins plays a key role in many cellular processes, including cell polarity and cell fate determination. Using DNA microarray analysis, we identified a plasma membrane protein-encoding mRNA...
10.
Khan S, Pierce D, Vale R
Curr Biol
. 2000 Aug;
10(15):927-30.
PMID: 10959841
The chemotaxis signal protein CheY of enteric bacteria shuttles between transmembrane methyl-accepting chemotaxis protein (MCP) receptor complexes and flagellar basal bodies [1]. The basal body C-rings, composed of the FliM,...