R C Skoda
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Explore the profile of R C Skoda including associated specialties, affiliations and a list of published articles.
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31
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1190
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Recent Articles
11.
Skoda R
J Recept Signal Transduct Res
. 1999 Mar;
19(1-4):741-72.
PMID: 10071797
The helical cytokines constitute a family of proteins with a common three-dimensional structure. They exert a wide variety of biological effects with a preference for the hematopoietic system. The effects...
12.
Stoffel R, Ziegler S, Ghilardi N, Ledermann B, de Sauvage F, Skoda R
Proc Natl Acad Sci U S A
. 1999 Jan;
96(2):698-702.
PMID: 9892696
The question of whether extracellular signals influence hematopoiesis by instructing stem cells to commit to a specific hematopoietic lineage (instructive model) or solely by permitting the survival and proliferation of...
13.
Ghilardi N, Wiestner A, Skoda R
Blood
. 1998 Dec;
92(11):4023-30.
PMID: 9834204
Thrombopoietin (TPO) is a lineage-dominant hematopoietic cytokine that regulates megakaryopoiesis and platelet production. The major site of TPO biosynthesis is the liver. Despite easily detectable levels of liver TPO mRNA,...
14.
Harrison C, Gale R, Wiestner A, Skoda R, Linch D
Br J Haematol
. 1998 Sep;
102(5):1341-3.
PMID: 9753068
Essential thrombocythaemia (ET) is a condition of unknown aetiology characterized by sustained thrombocytosis in the absence of a detectable systemic cause. Although usually considered a clonal disease affecting myeloid cells,...
15.
Hakansson M, Brown H, Ghilardi N, Skoda R, Meister B
J Neurosci
. 1998 Jan;
18(1):559-72.
PMID: 9412531
The adipose tissue-derived hormone leptin regulates body weight homeostasis by decreasing food intake and increasing energy expenditure. The weight-reducing action of leptin is thought to be mediated primarily by signal...
16.
Wiestner A, Schlemper R, van der Maas A, Skoda R
Nat Genet
. 1998 Jan;
18(1):49-52.
PMID: 9425899
Essential thrombocythaemia (ET) is a chronic myeloproliferative syndrome due to sustained proliferation of megakaryocytes, which results in elevated numbers of circulating platelets, thrombotic or haemorrhagic episodes and occasional leukaemic transformation....
17.
Skoda R, Tichelli A, Tyndall A, Hoffmann T, Gillessen S, Gratwohl A
Br J Haematol
. 1997 Nov;
99(1):56-7.
PMID: 9359502
Immunoablation by high-dose chemotherapy followed by autologous peripheral blood stem cell transplantation (PBSCT) is one approach currently under discussion for the treatment and possible cure of patients with severe autoimmune...
18.
Ghilardi N, Skoda R
Mol Endocrinol
. 1997 Apr;
11(4):393-9.
PMID: 9092791
The antiobesity effects of leptin are mediated by the obese receptor (OB-R), a member of the cytokine receptor superfamily. Several isoforms of OB-R that differ in the length of the...
19.
Ghilardi N, Ziegler S, Wiestner A, Stoffel R, Heim M, Skoda R
Proc Natl Acad Sci U S A
. 1996 Jun;
93(13):6231-5.
PMID: 8692797
Leptin and its receptor, obese receptor (OB-R), comprise an important signaling system for the regulation of body weight. Splice variants of OB-R mRNA encode proteins that differ in the length...
20.
Stoffel R, Wiestner A, Skoda R
Blood
. 1996 Jan;
87(2):567-73.
PMID: 8555478
Thrombopoietin (TPO), originally described as an activity in the serum of thrombocytopenic animals that leads to increased production of platelets, has recently been isolated and cloned. Its closest relative in...