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R C Seeger

Explore the profile of R C Seeger including associated specialties, affiliations and a list of published articles. Areas
Snapshot
Articles 155
Citations 5482
Followers 0
Related Specialties
Oncology
General Medicine
Biology
Top 10 Co-Authors
C P Reynolds
K K Matthay
G M Brodeur
D O Stram
H Shimada
J N Lukens
G M Haase
R B Gerbing
T J Moss
J B Atkinson
Published In
Prog Clin Biol Res
J Clin Oncol
Cancer Res
Med Pediatr Oncol
J Immunol
Affiliations
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Recent Articles
1.
Augmented expression of MYC and/or MYCN protein defines highly aggressive MYC-driven neuroblastoma: a Children's Oncology Group study
Wang L, Teshiba R, Ikegaki N, Tang X, Naranjo A, London W, et al.
Br J Cancer . 2015 Jun; 113(1):57-63. PMID: 26035700
Background: MYCN amplification with subsequent MYCN protein overexpression is a powerful indicator of poor prognosis of neuroblastoma patients. Little is known regarding the prognostic significance of the homologous MYC protein...
2.
Antibody targeting of anaplastic lymphoma kinase induces cytotoxicity of human neuroblastoma
Carpenter E, Haglund E, Mace E, Deng D, Martinez D, Wood A, et al.
Oncogene . 2012 Jan; 31(46):4859-67. PMID: 22266870
Anaplastic lymphoma kinase (ALK) is a receptor tyrosine kinase aberrantly expressed in neuroblastoma, a devastating pediatric cancer of the sympathetic nervous system. Germline and somatically acquired ALK aberrations induce increased...
3.
Consensus criteria for sensitive detection of minimal neuroblastoma cells in bone marrow, blood and stem cell preparations by immunocytology and QRT-PCR: recommendations by the International Neuroblastoma Risk Group Task Force
Beiske K, Burchill S, Cheung I, Hiyama E, Seeger R, Cohn S, et al.
Br J Cancer . 2009 Apr; 100(10):1627-37. PMID: 19401690
Disseminating disease is a predictive and prognostic indicator of poor outcome in children with neuroblastoma. Its accurate and sensitive assessment can facilitate optimal treatment decisions. The International Neuroblastoma Risk Group...
4.
Evidence for an age cutoff greater than 365 days for neuroblastoma risk group stratification in the Children's Oncology Group
London W, Castleberry R, Matthay K, Look A, Seeger R, Shimada H, et al.
J Clin Oncol . 2005 Aug; 23(27):6459-65. PMID: 16116153
Purpose: In the Children's Oncology Group, risk group assignment for neuroblastoma is critical for therapeutic decisions, and patients are stratified by International Neuroblastoma Staging System stage, MYCN status, ploidy, Shimada...
5.
Expression of CD1d by myelomonocytic leukemias provides a target for cytotoxic NKT cells
Metelitsa L, Weinberg K, Emanuel P, Seeger R
Leukemia . 2003 May; 17(6):1068-77. PMID: 12764370
Natural killer T (NKT) cells with an invariant T-cell receptor for alpha-galactosylceramide (alphaGalCer) that is presented by CD1d have been reported to be cytotoxic for myelomonocytic leukemia cells. However, the...
6.
Buthionine sulfoximine and myeloablative concentrations of melphalan overcome resistance in a melphalan-resistant neuroblastoma cell line
Anderson C, Seeger R, Satake N, Keshelava N, Bailey H, Reynolds C
J Pediatr Hematol Oncol . 2002 Mar; 23(8):500-5. PMID: 11878777
Background: Alkylator resistance contributes to treatment failure in high-risk neuroblastoma. Buthionine sulfoximine (BSO) can deplete glutathione and synergistically enhance in vitro sensitivity to the alkylating agent melphalan (L-PAM) for many...
7.
Histopathology (International Neuroblastoma Pathology Classification) and MYCN status in patients with peripheral neuroblastic tumors: a report from the Children's Cancer Group
Goto S, Umehara S, Gerbing R, Stram D, Brodeur G, Seeger R, et al.
Cancer . 2001 Dec; 92(10):2699-708. PMID: 11745206
Background: The International Neuroblastoma Pathology Classification (International Classification), which was established in 1999, is significant prognostically and is relevant biologically for the evaluation and analysis of patients with neuroblastic tumors...
8.
Human NKT cells mediate antitumor cytotoxicity directly by recognizing target cell CD1d with bound ligand or indirectly by producing IL-2 to activate NK cells
Metelitsa L, Naidenko O, Kant A, Wu H, Loza M, Perussia B, et al.
J Immunol . 2001 Sep; 167(6):3114-22. PMID: 11544296
alpha-Galactosylceramide (alphaGalCer) stimulates NKT cells and has antitumor activity in mice. Murine NKT cells may directly kill tumor cells and induce NK cell cytotoxicity, but the mechanisms are not well...
9.
Ganglioside GM2/GD2 synthetase mRNA is a marker for detection of infrequent neuroblastoma cells in bone marrow
Hoon D, Kuo C, Wen S, Wang H, Metelitsa L, Reynolds C, et al.
Am J Pathol . 2001 Aug; 159(2):493-500. PMID: 11485908
GalNAcbeta1-4(NeuAcalpha2-3)Galbeta1-4Glcbeta1-Cer (GM2)/GalNAcbeta1-4(NeuAcalpha2-8NeuAcalpha2-3)Galbeta1-4Glcbeta1-1Cer (GD2) synthetase [beta-1,4-N-acetyl-galactosaminyl transferase (GalNAc-T)] mRNA, which encodes a key glycosyltransferase for ganglioside GD2 synthesis, was assessed as a molecular marker for detecting metastatic neuroblastoma cells in bone...
10.
Comprehensive analysis of chromosome 1p deletions in neuroblastoma
Maris J, Guo C, Blake D, White P, Hogarty M, Thompson P, et al.
Med Pediatr Oncol . 2001 Jul; 36(1):32-6. PMID: 11464900
Background: Chromosome 1p deletions are common in advanced neuroblastomas, but the biological and clinical implications of this clonal rearrangement remain controversial. Previous studies of chromosome 1p loss of heterozygosity (LOH)...