R C Pierce
Overview
Explore the profile of R C Pierce including associated specialties, affiliations and a list of published articles.
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57
Citations
2183
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Recent Articles
1.
Wimmer M, Briand L, Fant B, Guercio L, Arreola A, Schmidt H, et al.
Mol Psychiatry
. 2017 Mar;
22(11):1653.
PMID: 28322277
This corrects the article DOI: 10.1038/mp.2017.8.
2.
Wimmer M, Briand L, Fant B, Guercio L, Arreola A, Schmidt H, et al.
Mol Psychiatry
. 2017 Feb;
22(11):1641-1650.
PMID: 28220045
Paternal environmental perturbations including exposure to drugs of abuse can produce profound effects on the physiology and behavior of offspring via epigenetic modifications. Here we show that adult drug-naive male...
3.
Schmidt H, McFarland K, Darnell S, Huizenga M, Sangrey G, Cha J, et al.
Mol Psychiatry
. 2014 Oct;
20(11):1460-6.
PMID: 25349168
Activation of AMPA receptors (AMPARs) in the nucleus accumbens is necessary for the reinstatement of cocaine-seeking behavior, an animal model of drug craving and relapse. AMPARs are tetrameric protein complexes...
4.
Vassoler F, Byrnes E, Pierce R
Neuropharmacology
. 2013 Jul;
76 Pt B:269-75.
PMID: 23810828
It is clear that both genetic and environmental factors contribute to drug addiction. Recent evidence indicating trans-generational influences of drug abuse highlight potential epigenetic factors as well. Specifically, mounting evidence...
5.
Gandal M, Sisti J, Klook K, Ortinski P, Leitman V, Liang Y, et al.
Transl Psychiatry
. 2012 Jul;
2:e142.
PMID: 22806213
Reduced N-methyl-D-aspartate-receptor (NMDAR) signaling has been associated with schizophrenia, autism and intellectual disability. NMDAR-hypofunction is thought to contribute to social, cognitive and gamma (30-80 Hz) oscillatory abnormalities, phenotypes common to...
6.
Schmidt H, Famous K, Pierce R
Eur J Neurosci
. 2009 Oct;
30(7):1358-69.
PMID: 19788581
The direct glutamatergic projection from the medial prefrontal cortex (mPFC) to the nucleus accumbens plays a critical role in mediating the reinstatement of cocaine seeking behavior. The mPFC also sends...
7.
Sadri-Vakili G, Janis G, Pierce R, Gibbs T, Farb D
J Pharmacol Exp Ther
. 2008 Sep;
327(3):840-5.
PMID: 18772319
The balance between GABA-mediated inhibitory and glutamate-mediated excitatory synaptic transmission represents a fundamental mechanism for controlling nervous system function, and modulators that can alter this balance may participate in the...
8.
Schmidt H, Pierce R
Neuroscience
. 2006 Jul;
142(2):451-61.
PMID: 16844308
Activation of D1-like (D1, D5) or D2-like (D1, D3, D4) dopamine receptors in the nucleus accumbens shell is sufficient to reinstate cocaine-seeking behavior in rats. The goal of these experiments...
9.
BARI A, Pierce R
Neuroscience
. 2005 Aug;
135(3):959-68.
PMID: 16111825
Cocaine self-administration experiments were designed to assess the respective roles of D1-like and D2-like dopamine receptors in the ventral forebrain in cocaine reinforcement. D1-like or D2-like dopamine receptor antagonists were...
10.
Anderson S, Pierce R
Pharmacol Ther
. 2005 Jun;
106(3):389-403.
PMID: 15922019
The transition from casual drug use to addiction, and the intense drug craving that accompanies it, has been postulated to result from neuroadaptations within the limbic system caused by repeated...