R C Koehler
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Explore the profile of R C Koehler including associated specialties, affiliations and a list of published articles.
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155
Citations
1598
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Recent Articles
11.
Bhardwaj A, Northington F, Carhuapoma J, Falck J, Harder D, Traystman R, et al.
Am J Physiol Heart Circ Physiol
. 2000 Sep;
279(4):H1616-24.
PMID: 11009448
Epoxyeicosatrienoic acids are cerebral vasodilators produced in astrocytes by cytochrome P-450 epoxygenase activity. The P-450 inhibitor miconazole attenuates the increase in cerebral blood flow (CBF) elicited by glutamate. We evaluated...
12.
Dore S, Goto S, Sampei K, Blackshaw S, Hester L, Ingi T, et al.
Neuroscience
. 2000 Sep;
99(4):587-92.
PMID: 10974422
Heme oxygenase (HO) cleaves the heme ring to form biliverdin, which is rapidly reduced to bilirubin, carbon monoxide, and iron. HO1, the first form of the enzyme discovered, is an...
13.
Bhardwaj A, Harukuni I, Murphy S, Alkayed N, Crain B, Koehler R, et al.
Stroke
. 2000 Jul;
31(7):1694-701.
PMID: 10884475
Background And Purpose: Hypertonic saline (HS) has been advocated as a hyperosmolar agent for the treatment of cerebral edema, especially after traumatic brain injury. We tested the hypothesis that continuous...
14.
Okada T, Watanabe Y, Brusilow S, Traystman R, Koehler R
Am J Physiol Heart Circ Physiol
. 2000 Apr;
278(5):H1577-84.
PMID: 10775136
Glutamine is purported to inhibit recycling of citrulline to arginine and to limit nitric oxide release in vitro. However, vasoactive effects of glutamine have not been clearly demonstrated in vivo....
15.
Dore S, Sampei K, Goto S, Alkayed N, Guastella D, Blackshaw S, et al.
Mol Med
. 1999 Dec;
5(10):656-63.
PMID: 10602774
Heme oxygenase (HO) is believed to be a potent antioxidant enzyme in the nervous system; it degrades heme from heme-containing proteins, giving rise to carbon monoxide, iron, and biliverdin, which...
16.
Sherman D, Brambrink A, Ichord R, Dasika V, Koehler R, Traystman R, et al.
Clin Electroencephalogr
. 1999 Oct;
30(4):175-83.
PMID: 10513324
This study examined the course of EEG recovery in an animal model of hypoxic-ischemic injury. The model used periods of hypoxia, room air and asphyxia to induce cardiac arrest. One-week-old...
17.
Brambrink A, Martin L, Hanley D, Becker K, Koehler R, Traystman R
J Cereb Blood Flow Metab
. 1999 Aug;
19(8):927-38.
PMID: 10458600
In neonates, asphyxia is a common cause of neuronal injury and often results in seizures. The authors evaluated whether blockade of alpha-amino-3-hydroxy-5-methylisoxazole-4-propionic acid (AMPA) receptors during asphyxia and early recovery...
18.
Shaffner D, Eleff S, Brambrink A, Sugimoto H, Izuta M, Koehler R, et al.
Crit Care Med
. 1999 Aug;
27(7):1335-42.
PMID: 10446829
Objectives: To test the hypothesis that greater cerebral perfusion pressure (CPP) is required to restore cerebral blood flow (CBF), oxygen metabolism, adenosine triphosphate (ATP), and intracellular pH (pHi) levels after...
19.
Northington F, Traystman R, Koehler R, Martin L
J Neurobiol
. 1999 Jun;
39(4):515-26.
PMID: 10380073
Glutamate transport is a primary mechanism for regulating extracellular levels of glutamate in the central nervous system. GLT1, the most abundant of the known high-affinity glutamate transporters, is found exclusively...
20.
Sharan M, Popel A, Hudak M, Koehler R, Traystman R, Jones Jr M
Ann Biomed Eng
. 1999 Jun;
26(1):48-59.
PMID: 10355550
Cerebral blood flow (CBF) increases as arterial oxygen content falls with hypoxic (low PO2), anemic (low hemoglobin) and carbon monoxide (CO) (high carboxyhemoglobin) hypoxia. Despite a higher arterial PO2, CO...