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R C Klann

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Articles 12
Citations 65
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Recent Articles
1.
Leung W, Chen A, Klann R, Moss T, Davis J, Noga S, et al.
Bone Marrow Transplant . 1998 Dec; 22(10):971-9. PMID: 9849694
Many poor-risk neuroblastomas and tumours of the Ewing's sarcoma family (ET) recur despite autologous transplants. Recurrence may be due to tumor cells contained in the BM harvests or PBSC harvests....
2.
Bercu B, Usala S, Klann R, Root A, Nguyen U, Torres B, et al.
Thyroid . 1996 Jun; 6(3):189-94. PMID: 8837325
Thyroid hormone resistance syndromes, which result from heterozygous mutations in the beta 1 thyroid hormone receptor gene, are sometimes associated with adult short stature, but more frequently with delayed bone...
3.
Weber A, Toppari J, Harvey R, Klann R, Shaw N, Ricker A, et al.
J Clin Endocrinol Metab . 1995 Jan; 80(1):65-71. PMID: 7829641
Familial glucocorticoid deficiency is an autosomal recessive syndrome of adrenal unresponsiveness to ACTH characterized by glucocorticoid deficiency, high plasma ACTH levels, and a normal renin-aldosterone axis. Defects of the ACTH...
4.
Klann R, Torres B, Menke J, Holbrook C, Bercu B, Usala S
J Clin Endocrinol Metab . 1993 Oct; 77(4):969-75. PMID: 8408473
Mutations in the T3-binding domain of the thyroid hormone receptor gene c-erbA beta result in dominant negative proteins and thyroid hormone resistance syndromes. Variable clinical manifestations of resistance to thyroid...
5.
Klann R, Holbrook C, Nyce J
Anticancer Res . 1992 May; 12(3):781-7. PMID: 1535769
In light of the discouraging results obtained with conventional chemotherapy of human colon cancer using 5-fluorouracil, we examined the effects of cis-diamminedichloroplatinum (cisplatin) alone and combined with 3'-deoxy-3'-azidothymidine (AZT) on...
6.
Schulz S, Klann R, Schonfeld S, Nyce J
Cancer Res . 1992 Mar; 52(5):1372-6. PMID: 1531325
We have previously demonstrated that the chemopreventive agent dehydroepiandrosterone (DHEA) inhibits the isoprenylation of cellular proteins by depletion of endogenous mevalonate. We now report that treatment of HT-29 SF human...
7.
Cameron G, Baldwin J, Klann R, Patrick K, Fischer S
Cancer Res . 1991 Oct; 51(20):5642-8. PMID: 1913682
The ability of the hyperplasiogenic irritant ethyl phenylpropiolate (EPP) to act as a tumor promoter in two-stage carcinogenesis and to stimulate cellular events commonly cited as markers of tumor promoter...
8.
Nyce J, Klann R, Holbrook C
Cancer Commun . 1990 Jan; 2(6):213-7. PMID: 2143076
Exposure to dehydroepiandrosterone caused a concentration-dependent accumulation of HT-29 human colonic adenocarcinoma cells in S-phase and sensitization toward the cytotoxic effects of fluorouracil deoxyriboside but not 5-fluorouracil. These effects were...
9.
Fischer S, Jasheway D, Klann R, Butler A, Patrick K, Baldwin J, et al.
Cancer Res . 1989 Dec; 49(23):6693-9. PMID: 2819717
The activation of protein kinase C, induction of ornithine decarboxylase (ODC), and hyperplasia have been suggested to be linked, sequential processes resulting from phorbol ester application to mouse skin. However,...
10.
Klann R, Fitzgerald D, Piccoli C, Slaga T, Yamasaki H
Cancer Res . 1989 Feb; 49(3):699-705. PMID: 2463079
Homologous and heterologous gap-junctional intercellular communication (IC) was characterized in a panel of cell lines derived from selected stages of SENCAR mouse skin carcinogenesis. This panel included a "carcinogen-altered" cell...