R C Bast Jr
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Explore the profile of R C Bast Jr including associated specialties, affiliations and a list of published articles.
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264
Citations
5668
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Recent Articles
1.
Mathieu K, Bedi D, Thrower S, Qayyum A, Bast Jr R
Ultrasound Obstet Gynecol
. 2017 Jun;
51(3):293-303.
PMID: 28639753
No abstract available.
2.
Washington M, Suh G, Orozco A, Sutton M, Yang H, Wang Y, et al.
Cell Death Dis
. 2015 Aug;
6:e1836.
PMID: 26247722
Autophagy can sustain or kill tumor cells depending upon the context. The mechanism of autophagy-associated cell death has not been well elucidated and autophagy has enhanced or inhibited sensitivity of...
3.
Lu Z, Yang H, Sutton M, Yang M, Clarke C, Liao W, et al.
Cell Death Differ
. 2014 Apr;
21(8):1275-89.
PMID: 24769729
The process of autophagy has been described in detail at the molecular level in normal cells, but less is known of its regulation in cancer cells. Aplasia Ras homolog member...
4.
Bast Jr R
Ann Oncol
. 2011 Dec;
22 Suppl 8:viii5-viii15.
PMID: 22180401
Cytoreductive surgery and empirical combination chemotherapy have improved 5-year survival for ovarian cancer patients, but have not increased the overall rate of cure. Poor outcomes relate, at least in part,...
5.
6.
Badgwell D, Lu Z, Le K, Gao F, Yang M, Suh G, et al.
Oncogene
. 2011 Jun;
31(1):68-79.
PMID: 21643014
Ovarian cancers migrate and metastasize over the surface of the peritoneal cavity. Consequently, dysregulation of mechanisms that limit cell migration may be particularly important in the pathogenesis of the disease....
7.
Bast Jr R, Mills G
Methods Mol Med
. 2011 Feb;
39:37-48.
PMID: 21340756
More than 90% of epithelial ovarian cancers are clonal neoplasms that arise from the progeny of a single cell (1-3). Comparison of primary and metastatic sites from the same patient...
8.
Fu S, Kavanagh J, Hu W, Bast Jr R
Int J Gynecol Cancer
. 2006 Oct;
16(5):1717-32.
PMID: 17009963
Platinum remains the most active drug class in ovarian cancer treatment; however, new single-agent and combination therapies are needed to improve the clinical outcome of ovarian cancer therapies. Oxaliplatin, a...
9.
Wen X, Yang G, Mao W, Thornton A, Liu J, Bast Jr R, et al.
Oncogene
. 2006 May;
25(52):6986-96.
PMID: 16715132
We determined the impact of HER2 signaling on two proangiogenic factors, vascular endothelial growth factor (VEGF) and interleukin-8 (IL-8), and on an antiangiogenic factor, thrombospondin-1 (TSP-1). Re-expression of HER2 in...
10.
Bast Jr R, Badgwell D, Lu Z, Marquez R, Rosen D, Liu J, et al.
Int J Gynecol Cancer
. 2005 Dec;
15 Suppl 3:274-81.
PMID: 16343244
A variety of biomarkers have been developed to monitor growth of ovarian cancer and to detect disease at an early interval. CA125 (MUC16) has provided a useful serum tumor marker...